ReviewNeuroscience letters2011
Targets for preventing epilepsy following cortical injury.
Review in Neuroscience letters, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- The damaged connectome: Mechanisms and consequences of brain network reorganization following neurotrauma.Neuroimage. Reports · 2026Review
- Inflammation in epileptogenesis after traumatic brain injury.Journal of neuroinflammation · 2017Review
- Aberrant excitatory rewiring of layer V pyramidal neurons early after neocortical trauma.Neurobiology of disease · 2016Article
- Physiological consequences of abnormal connectivity in a developmental epilepsy.Annals of neurology · 2015Article
- Excitatory and inhibitory synaptic connectivity to layer V fast-spiking interneurons in the freeze lesion model of cortical microgyria.Journal of neurophysiology · 2014Article
- Can structural or functional changes following traumatic brain injury in the rat predict epileptic outcome?Epilepsia · 2013Article
- Small-molecule modulation of neurotrophin receptors: a strategy for the treatment of neurological disease.Nature reviews. Drug discovery · 2013Review
- Carbenoxolone pretreatment and treatment of posttraumatic epilepsy.Neural regeneration research · 2013Article
- Finding a better drug for epilepsy: antiepileptogenesis targets.Epilepsia · 2012Review
- Functional alterations in GABAergic fast-spiking interneurons in chronically injured epileptogenic neocortex.Neurobiology of disease · 2012Article
- Posttraumatic Epilepsy: What's Contusion Got to Do With It?Epilepsy currents · 2012Article
- New strategies for preventing epileptogenesis: perspective and overview.Neuroscience letters · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Prophylaxis of posttraumatic epilepsy will require a detailed knowledge of the epileptogenic pathophysiological processes that follow brain injury. Results from studies of experimental models and human epilepsy highlight alterations in GABAergic interneurons and formation of excessive new excitatory synaptic connectivity as prominent targets for prophylactic therapies. Promising laboratory results suggest that it will be possible to experimentally modify these aberrant processes and interfere with epileptogenesis. However, a number of key issues must be addressed before these results can be used to frame clinical antiepileptogenic therapy.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.