SynthesisJournal of hepatology2011
Hemochromatosis gene and nonalcoholic fatty liver disease: a systematic review and meta-analysis.
Synthesis in Journal of hepatology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- HFE genetic variability and risk of alcoholic liver disease: A meta-analysis.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2016Pooled it
- Genetic factors that affect nonalcoholic fatty liver disease: A systematic clinical review.World journal of gastroenterology · 2016Pooled it
- Hemochromatosis gene and nonalcoholic fatty liver disease: a systematic review and meta-analysis.Journal of hepatology · 2011Pooled it
- Association between pattern of hepatic iron deposition and severity of MASH among patients enrolled in the NASH Clinical Research Network.Hepatology communications · 2025Article
- Exploring the Multifaceted Landscape of MASLD: A Comprehensive Synthesis of Recent Studies, from Pathophysiology to Organoids and Beyond.Biomedicines · 2024Review
- A decade of iron overload disorders and hemochromatosis: clinical and genetic findings from a specialized center in Colombia.Frontiers in medicine · 2024Article
- Secondary Iron Overload and the Liver: A Comprehensive Review.Journal of clinical and translational hepatology · 2023Review
- Genetic variants in HFE are associated with non-alcoholic fatty liver disease in lean individuals.JHEP reports : innovation in hepatology · 2023Article
- Multiparametric MR mapping in clinical decision-making for diffuse liver disease.Abdominal radiology (New York) · 2020Review
- Iron and non-alcoholic fatty liver disease.World journal of gastroenterology · 2016Review
- A Guide to Non-Alcoholic Fatty Liver Disease in Childhood and Adolescence.International journal of molecular sciences · 2016Review
- Genetic background in nonalcoholic fatty liver disease: A comprehensive review.World journal of gastroenterology · 2015Review
- Composite prognostic models across the non-alcoholic fatty liver disease spectrum: Clinical application in developing countries.World journal of hepatology · 2015Review
- Evolving concepts in the pathogenesis of NASH: beyond steatosis and inflammation.International journal of molecular sciences · 2014Review
- Genetic predisposition in NAFLD and NASH: impact on severity of liver disease and response to treatment.Current pharmaceutical design · 2013Article
- Lower serum hepcidin and greater parenchymal iron in nonalcoholic fatty liver disease patients with C282Y HFE mutations.Hepatology (Baltimore, Md.) · 2012Article
- Iron metabolism in Nonalcoholic Fatty Liver Disease.Current gastroenterology reports · 2012Review
- Non-alcoholic fatty liver disease: is iron relevant?Hepatology international · 2012Article
- Cryptogenic chronic hepatitis and its changing guise in adults.Digestive diseases and sciences · 2011Review
- Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
BACKGROUND &
aimsPrevious studies examining the relationship between the C282Y and H63D HFE mutations and presence of nonalcoholic fatty liver disease (NAFLD) have yielded conflicting results. The goal of this study was to systematically evaluate and summarize data on the association between these two variants and the presence of NAFLD.
methodsThe authors searched EMBASE and PUBMED from August 1, 1996 to August 12, 2010. Two investigators independently conducted data abstraction. Ethnic specific weighted prevalence was calculated and pooled odds ratios were estimated using the random effects model.
resultsFrom 2542 references, the authors included 16 case-control studies and 14 case-only studies, or 2610 cases and 7298 controls. The majority of the studies came from Caucasian populations (2287 cases and 4275 controls). The weighted prevalence of HFE mutations in cases was comparable to controls. The meta-analysis was restricted to Caucasians only because of the small sample size of non Caucasian participants. The pooled odds ratio for the presence of any HFE genetic variant in cases was 1.03 (95%CI: 0.90, 1.17; I(2): 65.8%, 95%CI: 38.5, 81.0). The presence of other genotypes and secondary analyses yielded similar non significant findings.
conclusionsOur systematic review does not support an association between the HFE genetic variants and the presence of NAFLD.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.