ArticleDevelopmental biology2011
Promotion of avian endothelial cell differentiation by GATA transcription factors.
Article in Developmental biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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Who cites it
7 citing papers in PubMed, 13 citations in OpenAlex.
- Molecular mechanism of synovial joint site specification and induction in developing vertebrate limbs.Development (Cambridge, England) · 2023Article
- A Human iPSC Double-Reporter System Enables Purification of Cardiac Lineage Subpopulations with Distinct Function and Drug Response Profiles.Cell stem cell · 2019Article
- High salt-induced excess reactive oxygen species production resulted in heart tube malformation during gastrulation.Journal of cellular physiology · 2018Article
- Autophagy is involved in ethanol-induced cardia bifida during chick cardiogenesis.Cell cycle (Georgetown, Tex.) · 2015Article
- Autophagy is involved in high glucose-induced heart tube malformation.Cell cycle (Georgetown, Tex.) · 2015Article
- BMP-mediated induction of GATA4/5/6 blocks somitic responsiveness to SHH.Development (Cambridge, England) · 2014Article
- Correlation of perfusion parameters with genes related to angiogenesis regulation in glioblastoma: a feasibility study.AJNR. American journal of neuroradiology · 2012Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
In the avian embryo, endothelial cells originate from several sources, including the lateral plate and somite mesoderm. In this study, we show that Gata transcription factors are expressed in the lateral plate and in vasculogenic regions of the avian somite and are able to promote a vascular endothelial fate when ectopically expressed in somite precursors. A fusion of GATA4 to the transcriptional activator VP16 promoted endothelium formation, indicating that GATA transcription factors promote vasculogenesis via activation of downstream targets, while a fusion of GATA4 to the transcriptional repressor engrailed repressed expression of Vascular Endothelial Growth Factor Receptor 2, a marker of endothelial precursors. These findings indicate a role for GATA transcription factors in the differentiation of the endothelium.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.