ArticleAnnals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology2011
Detection of immunological biomarkers correlated with asthma control and quality of life measurements in sera from chronic asthmatic patients.
Article in Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
- Longitudinal co-variations between inflammatory cytokines, lung function and patient reported outcomes in patients with asthma.PloS one · 2017Trial
- IL-3: key orchestrator of inflammation.Frontiers in immunology · 2024Review
- Creatine Kinase Is Decreased in Childhood Asthma.American journal of respiratory and critical care medicine · 2023Article
- Differences in Inflammatory Cytokine Profile in Obesity-Associated Asthma: Effects of Weight Loss.Journal of clinical medicine · 2022Article
- Article
- Proteomic and Phosphoproteomic Changes Induced by Prolonged Activation of Human Eosinophils with IL-3.Journal of proteome research · 2018Article
- IL-3 up-regulates and activates human eosinophil CD32 and αMβ2 integrin causing degranulation.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2017Article
- Essential Mechanisms of Differential Activation of Eosinophils by IL-3 Compared to GM-CSF and IL-5.Critical reviews in immunology · 2016Review
- IL-3 Maintains Activation of the p90S6K/RPS6 Pathway and Increases Translation in Human Eosinophils.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Deciphering Asthma Biomarkers with Protein Profiling Technology.International journal of inflammation · 2015Review
- Role of inflammasome activation in development and exacerbation of asthma.Asia Pacific allergy · 2014Review
- Activation states of blood eosinophils in asthma.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2014Review
- Semaphorin 7A is expressed on airway eosinophils and upregulated by IL-5 family cytokines.Clinical immunology (Orlando, Fla.) · 2014Article
- Anti-inflammatory effects of the Chinese herbal formula FAHF-2 in experimental and human IBD.Inflammatory bowel diseases · 2014Article
- Clinical utility of asthma biomarkers: from bench to bedside.Biologics : targets & therapy · 2013Review
- Immunolocalization of NLRP3 Inflammasome in Normal Murine Airway Epithelium and Changes following Induction of Ovalbumin-Induced Airway Inflammation.Journal of allergy · 2012Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundClinical outcomes of patients with asthma are highly variable. Immunological biomarkers associated with asthma control have not been elucidated.
objectiveTo identify the association between clinical control of asthma and serum immunological profiles of asthmatics and compare these profiles with those of healthy controls by using a multiplex assay.
methodsSera were obtained from 28 nonsmokers 18 to 55 years of age with moderate and severe persistent asthma. Patients were classified as having well-controlled (WC, n = 14) or poorly controlled (PC, n = 14) asthma based on their responses to the Asthma Control Questionnaire and Asthma Quality of Life Questionnaire. Sera from nonasthmatic control individuals (NAC, n = 14) were used for comparison. Levels of 50 analytes, including cytokines, chemokines, angiogenic, and growth factors, were determined, using a multiplex assay.
resultsTwelve of the 29 cytokines levels were significantly higher in patients with asthma than in NACs, but only interferon gamma levels were significantly lower in patients with asthma than in the NAC group. Among these, interleukin (IL)-3 and IL-18 levels were significantly higher in the PC group than the WC group. Five of the 12 tested chemokine levels were significantly higher in patients with asthma than in NACs. Five of six growth factor levels were significantly higher in patients with asthma than in NACs, and 3 were higher in PC than WC. Interleukin-18, fibroblast growth factor, hepatocyte growth factor, and stem cell growth factor-beta were positively correlated with poor asthma control and negatively with quality of life scores.
conclusionsIncreased serum levels of fibroblast growth factor, hepatocyte growth factor, and stem cell growth factor-beta might be useful biomarkers of asthma control status and targets of future asthma therapy.
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