ReviewPhysics of life reviews2011
The emergence of modularity in biological systems.
Review in Physics of life reviews, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
70 citing papers in PubMed, 41 citations in OpenAlex.
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- A desynchrony mechanism between events triggers a compensatory delay during Caenorhabditis elegans development.PLoS biology · 2026Article
- Gene regulatory networks: from correlative models to causal explanations.Nature reviews. Genetics · 2026Review
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- Desynchrony between events triggers a compensatory delay duringbioRxiv : the preprint server for biology · 2026Article
- Format-Preserving Reduction of Canonical Nonlinear Models.Bulletin of mathematical biology · 2026Article
- A Microbial-Centric View of Mobile Phones: Enhancing the Technological Feasibility of Biotechnological Recovery of Critical Metals.Bioengineering (Basel, Switzerland) · 2025Review
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- Community detection in the human connectome: Method types, differences and their impact on inference.Human brain mapping · 2024Article
- Bayesian inference is facilitated by modular neural networks with different time scales.PLoS computational biology · 2024Article
- Identifying Qingkailing ingredients-dependent mesenchymal-epithelial transition factor-axiation "π" structuring module with angiogenesis and neurogenesis effects.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2024Article
- Metabolic Connectome and Its Role in the Prediction, Diagnosis, and Treatment of Complex Diseases.Metabolites · 2024Review
- Life's building blocks: the modular path to multiscale complexity.Frontiers in systems biology · 2024Article
- Cities of the Anthropocene: urban sustainability in an eco-evolutionary perspective.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- A novel bioinformatics strategy to uncover the active ingredients and molecular mechanisms of Bai Shao in the treatment of non-alcoholic fatty liver disease.Frontiers in pharmacology · 2024Article
- Modularity of biological systems: a link between structure and function.Journal of the Royal Society, Interface · 2023Article
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- Internal control of brain networks via sparse feedback.AIChE journal. American Institute of Chemical Engineers · 2023Article
- Applying precision medicine principles to the management of multimorbidity: the utility of comorbidity networks, graph machine learning, and knowledge graphs.Frontiers in medicine · 2023Review
10 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
In this review, we discuss modularity and hierarchy in biological systems. We review examples from protein structure, genetics, and biological networks of modular partitioning of the geometry of biological space. We review theories to explain modular organization of biology, with a focus on explaining how biology may spontaneously organize to a structured form. That is, we seek to explain how biology nucleated from among the many possibilities in chemistry. The emergence of modular organization of biological structure will be described as a symmetry-breaking phase transition, with modularity as the order parameter. Experimental support for this description will be reviewed. Examples will be presented from pathogen structure, metabolic networks, gene networks, and protein-protein interaction networks. Additional examples will be presented from ecological food networks, developmental pathways, physiology, and social networks.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.