ArticleCurrent biology : CB2011
Identification of a polo-like kinase 4-dependent pathway for de novo centriole formation.
Article in Current biology : CB, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 39 citations in OpenAlex.
- Article
- Appearing and disappearing acts of cilia.Journal of biosciences · 2023Review
- Transmission ratio distortion of mutations in the master regulator of centriole biogenesis PLK4.Human genetics · 2022Article
- PLK4 Is a Potential Biomarker for Abnormal Tumor Proliferation, Immune Infiltration, and Prognosis in ccRCC.Computational and mathematical methods in medicine · 2022Article
- PLK4 is a microtubule-associated protein that self-assembles promotingJournal of cell science · 2018Article
- Review
- Effects of insulin-like growth factor-1 on the in vitro maturation of canine oocytes.The Journal of reproduction and development · 2018Article
- Article
- CDK1 Prevents Unscheduled PLK4-STIL Complex Assembly in Centriole Biogenesis.Current biology : CB · 2016Article
- The NIMA-like kinase Nek2 is a key switch balancing cilia biogenesis and resorption in the development of left-right asymmetry.Development (Cambridge, England) · 2015Article
- p53 protects against genome instability following centriole duplication failure.The Journal of cell biology · 2015Article
- The centriole duplication cycle.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2014Review
- Polo-like kinases: structural variations lead to multiple functions.Nature reviews. Molecular cell biology · 2014Review
- PIPKIγ targets to the centrosome and restrains centriole duplication.Journal of cell science · 2014Article
- Article
- Mitochondrial genome regulates mitotic fidelity by maintaining centrosomal homeostasis.Cell cycle (Georgetown, Tex.) · 2014Article
- Spindle formation in the mouse embryo requires Plk4 in the absence of centrioles.Developmental cell · 2013Article
- The centriolar satellite protein SSX2IP promotes centrosome maturation.The Journal of cell biology · 2013Article
- RhoD participates in the regulation of cell-cycle progression and centrosome duplication.Oncogene · 2013Article
- The structure of the plk4 cryptic polo box reveals two tandem polo boxes required for centriole duplication.Structure (London, England : 1993) · 2012Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Supernumerary centrosomes are a key cause of genomic instability in cancer cells. New centrioles can be generated by duplication with a mother centriole as a platform or, in the absence of preexisting centrioles, by formation de novo. Polo-like kinase 4 (Plk4) regulates both modes of centriole biogenesis, and Plk4 deregulation has been linked to tumor development. We show that Plx4, the Xenopus homolog of mammalian Plk4 and Drosophila Sak, induces de novo centriole formation in vivo in activated oocytes and in egg extracts, but not in immature or in vitro matured oocytes. Both kinase activity and the polo-box domain of Plx4 are required for de novo centriole biogenesis. Polarization microscopy in "cycling" egg extracts demonstrates that de novo centriole formation is independent of Cdk2 activity, a major difference compared to template-driven centrosome duplication that is linked to the nuclear cycle and requires cyclinA/E/Cdk2. Moreover, we show that the Mos-MAPK pathway blocks Plx4-dependent de novo centriole formation before fertilization, thereby ensuring paternal inheritance of the centrosome. The results define a new system for studying the biochemical and molecular basis of de novo centriole formation and centriole biogenesis in general.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.