ArticleBrain, behavior, and immunity2011
Epigenetic impact of simulated maternal grooming on estrogen receptor alpha within the developing amygdala.
Article in Brain, behavior, and immunity, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 73 citations in OpenAlex.
- Estrogens, age, and, neonatal stress: panic disorders and novel views on the contribution of non-medullary structures to respiratory control and COFrontiers in physiology · 2023Review
- Impact of a bisphenol A, F, and S mixture and maternal care on the brain transcriptome of rat dams and pups.Neurotoxicology · 2022Article
- Maternal low protein diet and fetal programming of lean type 2 diabetes.World journal of diabetes · 2022Review
- Effect of adverse childhood experiences and DNA methylation on male sexual orientation.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2021Article
- Novel sex-specific influence of parental factors on small-for-gestational-age newborns.Scientific reports · 2020Article
- Sexes on the brain: Sex as multiple biological variables in the neuronal control of feeding.Biochimica et biophysica acta. Molecular basis of disease · 2020Review
- The effects of early life adversity on growth, maturation, and steroid hormones in male and female rats.The European journal of neuroscience · 2020Article
- Psychiatric Disorders in the Adolescent Offspring of Mothers with Thyroid Problems During Pregnancy.Child psychiatry and human development · 2020Article
- Sex Differences in the Epigenome: A Cause or Consequence of Sexual Differentiation of the Brain?Genes · 2019Review
- DoesFrontiers in neuroscience · 2019Article
- Exposure to extrinsic stressors, social defeat or bisphenol A, eliminates sex differences in DNA methyltransferase expression in the amygdala.Journal of neuroendocrinology · 2017Article
- Sex Drives Dimorphic Immune Responses to Viral Infections.Journal of immunology (Baltimore, Md. : 1950) · 2017Review
- Genetic and epigenetic factors underlying sex differences in the regulation of gene expression in the brain.Journal of neuroscience research · 2017Review
- Epigenetic regulation of estrogen receptor α contributes to age-related differences in transcription across the hippocampal regions CA1 and CA3.Neurobiology of aging · 2017Article
- Sex differences in Gadd45b expression and methylation in the developing rodent amygdala.Brain research · 2016Article
- Cellular and molecular mechanisms of sexual differentiation in the mammalian nervous system.Frontiers in neuroendocrinology · 2016Review
- Influence of maternal care on the developing brain: Mechanisms, temporal dynamics and sensitive periods.Frontiers in neuroendocrinology · 2016Review
- At the frontier of epigenetics of brain sex differences.Frontiers in behavioral neuroscience · 2015Review
- Litter and sex effects on maternal behavior and DNA methylation of the Nr3c1 exon 17 promoter gene in hippocampus and cerebellum.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2014Article
- Epigenetic mechanisms in pubertal brain maturation.Neuroscience · 2014Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Variations in maternal care alter the developmental programming of some genes by creating lasting differences in DNA methylation patterns, such as the estrogen receptor alpha (ERα) promoter region. Interestingly, mother rats preferentially lick and groom their male offspring more than females; therefore, we questioned whether the somatosensory stimuli associated with maternal grooming influences potential sex differences in DNA methylation patterns within the developing amygdala, an area important for socioemotional processing. We report a sex difference in the DNA methylation pattern of specific CpG sites of the ERα promoter region within the developing amygdala. Specifically, males have higher levels of ERα promoter methylation contrasted to females. Increasing the levels of maternal stimuli in females masculinized ERα promoter methylation patterns to male-like levels. As expected, higher levels of ERα promoter methylation were associated with lower ERα mRNA levels. These data provide further evidence that the early neonatal environment, particularly maternal care, contributes to sex differences and early programming of the neonatal brain via an epigenetic mechanism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.