ReviewNeuroscience research2011
Excitation-transcription coupling in sympathetic neurons and the molecular mechanism of its initiation.
Review in Neuroscience research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 43 citations in OpenAlex.
- Inductive analysis of the spatial distribution characteristics of neurons that innervate skeletal muscle and their correlation with muscle phenotype.Neural regeneration research · 2026Article
- Inactivation of CaV1 and CaV2 channels.The Journal of general physiology · 2025Review
- Rat Sympathetic Neuron Calcium Channels Are Insensitive to Gabapentin.Pharmaceuticals (Basel, Switzerland) · 2024Article
- NRN1 epistasis with BDNF and CACNA1C: mediation effects on symptom severity through neuroanatomical changes in schizophrenia.Brain structure & function · 2024Article
- Effects of Treadmill Running at Different Light Cycles in Mice with Metabolic Disorders.International journal of molecular sciences · 2023Article
- Ouabain-Induced Cell Death and Survival. Role of α1-Na,K-ATPase-Mediated Signaling and [NaFrontiers in physiology · 2020Review
- Article
- SiOScientific reports · 2018Article
- CaChannels (Austin, Tex.) · 2017Article
- Na⁺Molecules (Basel, Switzerland) · 2017Review
- Time- and dose dependent actions of cardiotonic steroids on transcriptome and intracellular content of NaScientific reports · 2017Article
- Mitochondrial fusion dynamics is robust in the heart and depends on calcium oscillations and contractile activity.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Dynamic and Static Exercises Differentially Affect Plasma Cytokine Content in Elite Endurance- and Strength-Trained Athletes and Untrained Volunteers.Frontiers in physiology · 2017Article
- Skeletal muscle as an endocrine organ: Role of [NaGenes & diseases · 2015Article
- Tamoxifen induces cellular stress in the nervous system by inhibiting cholesterol synthesis.Acta neuropathologica communications · 2015Article
- Evolutionary and functional perspectives on signaling from neuronal surface to nucleus.Biochemical and biophysical research communications · 2015Review
- Salt and gene expression: evidence for [Na+]i/[K+]i-mediated signaling pathways.Pflugers Archiv : European journal of physiology · 2015Review
- Marinesco-Sjögren syndrome protein SIL1 regulates motor neuron subtype-selective ER stress in ALS.Nature neuroscience · 2015Article
- Exploring the dominant role of Cav1 channels in signalling to the nucleus.Bioscience reports · 2012Review
- Nanodomain Ca²⁺ of Ca²⁺ channels detected by a tethered genetically encoded Ca²⁺ sensor.Nature communications · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
In excitable cells, membrane depolarization and activation of voltage-gated Ca²+ (Ca(V)) channels trigger numerous cellular responses, including muscle contraction, secretion, and gene expression. Yet, while the mechanisms underlying excitation-contraction and excitation-secretion coupling have been extensively characterized, how neuronal activity is coupled to gene expression has remained more elusive. In this article, we will discuss recent progress toward understanding the relationship between patterns of channel activity driven by membrane depolarization and activation of the nuclear transcription factor CREB. We show that signaling strength is steeply dependent on membrane depolarization and is more sensitive to the open probability of Ca(V) channels than the Ca²+ entry itself. Furthermore, our data indicate that by decoding Ca(V) channel activity, CaMKII (a Ca²+/calmodulin-dependent protein kinase) links membrane excitation to activation of CREB in the nucleus. Together, these results revealed some interesting and unexpected similarities between excitation-transcription coupling and other forms of excitation-response coupling.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.