ArticleBMC microbiology2011
Quinolone resistance in Escherichia coli from Accra, Ghana.
Article in BMC microbiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 3 of them syntheses that pooled it.
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Who cites it
38 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Tracking of multidrug-resistant pathogen clones in Ghana: a systematic review and meta-analysis.BMC medical genomics · 2025Pooled it
- A systematic review and meta-analysis on antibiotic resistance genes in Ghana.BMC medical genomics · 2025Pooled it
- High prevalence of antibiotic resistance in commensal Escherichia coli from healthy human sources in community settings.Scientific reports · 2021Pooled it
- Changing paradigm of antibiotic resistance amongst Escherichia coli isolates in Indian pediatric population.PloS one · 2019Trial
- Molecular characterization of extended-spectrum beta-lactamase-producing Escherichia coli among children and farm animals in Agogo, Ghana.BMC microbiology · 2026Article
- Prevalence and Phenotypic Characterization of Antibiotic-resistantEthiopian journal of health sciences · 2024Article
- Antimicrobial Resistance ofInternational journal of microbiology · 2021Article
- High rates of multi-drug resistant gram-negative organisms associated with surgical site infections in a teaching hospital in Ghana.BMC infectious diseases · 2020Article
- Antibiotic resistance patterns in human, animal, food and environmental isolates in Ghana: a review.The Pan African medical journal · 2020Review
- Multi-Drug-Resistant DiarrheagenicInfection and drug resistance · 2020Article
- A large self-transmissible resistance plasmid from Nigeria contains genes that ameliorate a carrying cost.Scientific reports · 2019Article
- Antimicrobial resistance genes in Salmonella and Escherichia coli isolates from chicken droppings in Nairobi, Kenya.BMC research notes · 2019Article
- Phenotypic and molecular characterization of antimicrobial resistantThe Pan African medical journal · 2019Article
- High frequency of mutations inIranian journal of basic medical sciences · 2018Article
- An evaluation of multidrug-resistant Escherichia coli isolates in urinary tract infections from Aguascalientes, Mexico: cross-sectional study.Annals of clinical microbiology and antimicrobials · 2018Article
- Self-Medication with Antibiotics, Attitude and Knowledge of Antibiotic Resistance among Community Residents and Undergraduate Students in Northwest Nigeria.Diseases (Basel, Switzerland) · 2018Article
- Analytical profiling of mutations in quinolone resistance determining region of gyrA gene among UPEC.PloS one · 2018Article
- Pathogenic multiple antimicrobial resistant Escherichia coli serotypes in recreational waters of Mumbai, India: a potential public health risk.Environmental science and pollution research international · 2017Article
- Prevalence of Quinolone Resistance in Enterobacteriaceae from Sierra Leone and the Detection of qnrB Pseudogenes and Modified LexA Binding Sites.Antimicrobial agents and chemotherapy · 2016Article
- A retrospective audit of antibiotic prescriptions in primary health-care facilities in Eastern Region, Ghana.Health policy and planning · 2016Article
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5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundAntimicrobial resistance is under-documented and commensal Escherichia coli can be used as indicator organisms to study the resistance in the community. We sought to determine the prevalence of resistance to broad-spectrum antimicrobials with particular focus on the quinolones, which have recently been introduced in parts of Africa, including Ghana.
resultsForty (13.7%) of 293 E. coli isolates evaluated were nalidixic acid-resistant. Thirteen (52%) of 2006 and 2007 isolates and 10 (66.7%) of 2008 isolates were also resistant to ciprofloxacin. All but one of the quinolone-resistant isolates were resistant to three or more other antimicrobial classes. Sequencing the quinolone-resistance determining regions of gyrA and parC, which encode quinolone targets, revealed that 28 quinolone-resistant E. coli harboured a substitution at position 83 of the gyrA gene product and 20 of these isolates had other gyrA and/or parC substitutions. Horizontally-acquired quinolone-resistance genes qnrB1, qnrB2, qnrS1 or qepA were detected in 12 of the isolates. In spite of considerable overall diversity among E. coli from Ghana, as evaluated by multilocus sequence typing, 15 quinolone-resistant E. coli belonged to sequence type complex 10. Five of these isolates carried qnrS1 alleles.
conclusionsQuinolone-resistant E. coli are commonly present in the faecal flora of Accra residents. The isolates have evolved resistance through multiple mechanisms and belong to very few lineages, suggesting clonal expansion. Containment strategies to limit the spread of quinolone-resistant E. coli need to be deployed to conserve quinolone effectiveness and promote alternatives to their use.
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