ArticleVirology journal2011
Revised cutoff values of ALT and HBV DNA level can better differentiate HBeAg (-) chronic inactive HBV patients from active carriers.
Article in Virology journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Proportion and factors associated with Hepatitis B viremia in antiretroviral treatment naïve and experienced HIV co-infected Ghanaian patients.BMC infectious diseases · 2016Trial
- A Comprehensive Analysis of Inactive Hepatitis B Infection in a Cohort of Omani Patients.Oman medical journal · 2024Article
- Seroepidemiology of hepatitis B virus (HBV) and relationship to serum transaminase levels in Indian population.Journal of family medicine and primary care · 2024Article
- The Relationship between Viral Replication and the Severity of Hepatic Necroinflammatory Damage Changed before HBeAg Loss in Patients with Chronic Hepatitis B Virus Infection.Journal of clinical and translational hepatology · 2024Article
- Hepatitis B in Pediatric Population: Observational Retrospective Study in Romania.Life (Basel, Switzerland) · 2024Article
- HBsAg level defines different clinical phenotypes of HBeAg(-) chronic HBV infection related to HBV polymerase-specific CD8Frontiers in immunology · 2024Article
- Association between cumulative childhood blood lead exposure and hepatic steatosis in young Mexican adults.Environmental research · 2021Article
- Total Antioxidant Capacity in HBV Carriers, a Promising Biomarker for Evaluating Hepatic Fibrosis: A Pilot Study.Antioxidants (Basel, Switzerland) · 2021Article
- Utilizing Experimental Mouse Model to Identify Effectors of Hepatocellular Carcinoma Induced by HBx Antigen.Cancers · 2020Article
- Characteristics of an Outpatient Cohort with HBeAg-Negative Chronic Hepatitis B.Open access Macedonian journal of medical sciences · 2019Article
- Fibrosis assessment in patients with chronic hepatitis B virus (HBV) infection.Annals of translational medicine · 2017Review
- Relationship Between Obesity and Liver Enzymes Levels in Turner's Syndrome.Gastroenterology research · 2017Article
- Evaluation of serum HBV viral load, transaminases and histological features in chronic HBeAg-negative hepatitis B patients.Gastroenterology and hepatology from bed to bench · 2017Article
- ADVANCED LIVER INJURY IN PATIENTS WITH CHRONIC HEPATITIS B AND VIRAL LOAD BELOW 2,000 IU/mL.Revista do Instituto de Medicina Tropical de Sao Paulo · 2016Article
- Genetic diversity, viraemic and aminotransferases levels in chronic infected hepatitis B patients from Cameroon.BMC research notes · 2016Article
- Article
- How can we make decision for patients with chronic hepatitis B according to hepatitis B virus (HBV) DNA level?Hepatitis monthly · 2014Article
- The relationship of liver function tests to mixed exposure to lead and organic solvents.Annals of occupational and environmental medicine · 2013Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsELISA is still used as primary test for diagnosis HBV disease. However, ELISA-positive patients were marked as HBV inactive after confirmation with PCR and vice versa. Our aim was to assess the performance of new cut-off value of ALT, HBV DNA load and significance of AST as screening tool for HBeAg (-) chronic active or inactive patients in Pakistani population. MATERIALS AND
methodsIn a cross-sectional, cohort study, 567 HBeAg (-) patients followed for one year were selected. Patients with persistent elevated ALT than normal and HBV DNA ≥ 100,000 copies/mL were taken as active chronic. Diagnostic values for ALT, AST and HBV DNA load in HBV HBeAg (-) chronic active and inactive patients compared using receiver operation characteristic (ROC) curves.
resultsOf 567 HBeAg (-) patients, 228 were classified as chronic inactive and 339 as active. HBV infection was dominant in male. Serum ALT, AST and HBV DNA levels showed significant and high AUROC to differentiate chronic HBeAg (-) inactive patients from active. AUROC for Serum ALT, AST and HBV DNA were observed 0.997, 0.969 and 1.000, respectively. For revised cut off value for ALT (30 IU/L for male and 19 IU/L for female) and HBV DNA load ≥100,000 copies/mL, a PPV of 97%, NPV of 94%, a sensitivity of 98%, and a specificity of 92% was observed to discriminate active carriers from inactive carriers. We also observed 93.5% specificity, 83.1% sensitivity, 82% PPV and 89.5% NPV for AST ≤20 IU/L to differentiate inactive carriers from active ones in our study group.
conclusionsRevised cut off value of ALT and NIH derived HBV DNA value can better discriminate between HBeAg (-) chronic active and inactive patients.
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