ArticleBMC genomics2011
Expression profile analysis of the inflammatory response regulated by hepatocyte nuclear factor 4α.
Article in BMC genomics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 34 citations in OpenAlex.
- The role of HNF4α in adenocarcinoma.Biochemical Society transactions · 2026Review
- A Two-Sample Mendelian Randomization Study of Basophil Count and Risk of Gestational Diabetes Mellitus.International journal of women's health · 2025Article
- Distinct roles of Constitutive Photomorphogenesis Protein 1 homolog (COP1) in human hepatocyte models.Frontiers in molecular biosciences · 2025Article
- Expression of melatonin receptors and CD4 in the ovine thymus, lymph node, spleen and liver during early pregnancy.Immunology · 2020Article
- The concomitant loss of APC and HNF4α in adult hepatocytes does not contribute to hepatocarcinogenesis driven by β-catenin activation.Liver international : official journal of the International Association for the Study of the Liver · 2019Article
- Genome-wide prediction of cis-regulatory regions using supervised deep learning methods.BMC bioinformatics · 2018Article
- Microenvironment and tumor cells: two targets for new molecular therapies of hepatocellular carcinoma.Translational gastroenterology and hepatology · 2018Review
- A cross-species approach to identify transcriptional regulators exemplified for Dnajc22 and Hnf4a.Scientific reports · 2017Article
- Apoptosis signal-regulating kinase 1 mediates the inhibitory effect of hepatocyte nuclear factor-4α on hepatocellular carcinoma.Oncotarget · 2016Article
- Bisphenol A Disrupts HNF4α-Regulated Gene Networks Linking to Prostate Preneoplasia and Immune Disruption in Noble Rats.Endocrinology · 2016Article
- MicroRNA-34c is associated with emphysema severity and modulates SERPINE1 expression.BMC genomics · 2014Article
- Hepatocyte nuclear factor 4-alpha involvement in liver and intestinal inflammatory networks.World journal of gastroenterology · 2014Review
- JunD/AP1 regulatory network analysis during macrophage activation in a rat model of crescentic glomerulonephritis.BMC systems biology · 2013Article
- Genomic characterization of remission in juvenile idiopathic arthritis.Arthritis research & therapy · 2013Article
- The role of microRNAs in hepatocyte nuclear factor-4alpha expression and transactivation.Biochimica et biophysica acta · 2013Article
- Micro-RNAs in inflammatory diseases and as a link between inflammation and cancer.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2013Review
- MicroRNA-feedback loop as a key modulator of liver tumorigenesis and inflammation.World journal of gastroenterology · 2013Article
- Article
- Mucroporin-M1 inhibits hepatitis B virus replication by activating the mitogen-activated protein kinase (MAPK) pathway and down-regulating HNF4α in vitro and in vivo.The Journal of biological chemistry · 2012Article
- Study of the expression levels of Hepatocyte nuclear factor 4 alpha and 3 beta in patients with different outcome of HBV infection.Virology journal · 2012Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHepatocyte nuclear factor 4α (HNF4α), a liver-specific transcription factor, plays a significant role in liver-specific functions. However, its functions are poorly understood in the regulation of the inflammatory response. In order to obtain a genomic view of HNF4α in this context, microarray analysis was used to probe the expression profile of an inflammatory response induced by cytokine stimulation in a model of HNF4α knock-down in HepG2 cells.
resultsThe expression of over five thousand genes in HepG2 cells is significantly changed with the dramatic reduction of HNF4α concentration compared to the cells with native levels of HNF4α. Over two thirds (71%) of genes that exhibit differential expression in response to cytokine treatment also reveal differential expression in response to HNF4α knock-down. In addition, we found that a number of HNF4α target genes may be indirectly mediated by an ETS-domain transcription factor ELK1, a nuclear target of mitogen-activated protein kinase (MAPK).
conclusionThe results indicate that HNF4α has an extensive impact on the regulation of a large number of the liver-specific genes. HNF4α may play a role in regulating the cytokine-induced inflammatory response. This study presents a novel function for HNF4α, acting not only as a global player in many cellular processes, but also as one of the components of inflammatory response in the liver.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.