ArticleRetrovirology2011
Analysis of XMRV integration sites from human prostate cancer tissues suggests PCR contamination rather than genuine human infection.
Article in Retrovirology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed.
- Article
- Fake Science: XMRV, COVID-19, and the Toxic Legacy of Dr. Judy Mikovits.AIDS research and human retroviruses · 2020Article
- A trip down memory lane with Retrovirology.Retrovirology · 2019Article
- Xenotropic Murine Leukemia Virus-Related Virus and RNase L R462Q Variants in Iranian Patients With Sporadic Prostate Cancer.Iranian Red Crescent medical journal · 2015Article
- No association between XMRV or related gammaretroviruses in Australian prostate cancer patients.Virology journal · 2013Article
- Recombinant origin, contamination, and de-discovery of XMRV.Current opinion in virology · 2012Review
- Intrinsic DNA synthesis fidelity of xenotropic murine leukemia virus-related virus reverse transcriptase.The FEBS journal · 2012Article
- Article
- XMRV and prostate cancer--a 'final' perspective.Nature reviews. Urology · 2012Review
- Article
- In-depth investigation of archival and prospectively collected samples reveals no evidence for XMRV infection in prostate cancer.PloS one · 2012Article
- XMRV induces cell migration, cytokine expression and tumor angiogenesis: are 22Rv1 cells a suitable prostate cancer model?PloS one · 2012Article
- Susceptibility of human lymphoid tissue cultured ex vivo to xenotropic murine leukemia virus-related virus (XMRV) infection.PloS one · 2012Article
- Multiple sources of contamination in samples from patients reported to have XMRV infection.PloS one · 2012Article
- Analysis of single-nucleotide polymorphisms in patient-derived retrovirus integration sites reveals contamination from cell lines acutely infected by xenotropic murine leukemia virus-related virus.Journal of virology · 2011Article
- Equal versus equivalent access to the scientific literature.Retrovirology · 2011Article
- Gammaretroviral integration into nucleosomal target DNA in vivo.Journal of virology · 2011Article
- No association of xenotropic murine leukemia virus-related viruses with prostate cancer.PloS one · 2011Article
- XMRV as a human pathogen?Cell host & microbe · 2011Article
- No Evidence of XMRV or MuLV Sequences in Prostate Cancer, Diffuse Large B-Cell Lymphoma, or the UK Blood Donor Population.Advances in virology · 2011Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
XMRV is a gammaretrovirus associated in some studies with human prostate cancer and chronic fatigue syndrome. Central to the hypothesis of XMRV as a human pathogen is the description of integration sites in DNA from prostate tumour tissues. Here we demonstrate that 2 of 14 patient-derived sites are identical to sites cloned in the same laboratory from experimentally infected DU145 cells. Identical integration sites have never previously been described in any retrovirus infection. We propose that the patient-derived sites are the result of PCR contamination. This observation further undermines the notion that XMRV is a genuine human pathogen.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.