ArticleEvoDevo2011
Expression of myriapod pair rule gene orthologs.
Article in EvoDevo, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 49 citations in OpenAlex.
- Single-cell sequencing reveals potential novel insights into appendage-patterning and joint-development in a spider.Developmental dynamics : an official publication of the American Association of Anatomists · 2026Article
- Conserved and diverged embryonic expression patterns of panarthropod NK-Cluster genes and new evidence for CRE-shuffling.BMC ecology and evolution · 2026Article
- Article
- Arthropod Pax Gene Evolution: A Role for Vanessa Cardui Twin of Eyeless in Eye Development.Molecular biology and evolution · 2025Article
- Review of extra-embryonic tissues in the closest arthropod relatives, onychophorans and tardigrades.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Review
- The Nasonia pair-rule gene regulatory network retains its function over 300 million years of evolution.Development (Cambridge, England) · 2022Article
- A mosaic of conserved and novel modes of gene expression and morphogenesis in mesoderm and muscle formation of a larval bivalve.Organisms, diversity & evolution · 2022Article
- Article
- The embryonic expression pattern of a second, hitherto unrecognized, paralog of the pair-rule gene sloppy-paired in the beetle Tribolium castaneum.Development genes and evolution · 2020Article
- Embryonic development and secondary axis induction in the Brazilian white knee tarantula Acanthoscurria geniculata, C. L. Koch, 1841 (Araneae; Mygalomorphae; Theraphosidae).Development genes and evolution · 2020Article
- Embryonic expression of a Long Toll (Loto) gene in the onychophorans Euperipatoides kanangrensis and Cephalofovea clandestina.Development genes and evolution · 2018Article
- Embryonic expression patterns and phylogenetic analysis of panarthropod sox genes: insight into nervous system development, segmentation and gonadogenesis.BMC evolutionary biology · 2018Article
- Evidence for the temporal regulation of insect segmentation by a conserved sequence of transcription factors.Development (Cambridge, England) · 2018Article
- Dynamic patterning by the Drosophila pair-rule network reconciles long-germ and short-germ segmentation.PLoS biology · 2017Article
- Predicting Ancestral Segmentation Phenotypes from Drosophila to Anopheles Using In Silico Evolution.PLoS genetics · 2016Article
- Gene expression analysis reveals that Delta/Notch signalling is not involved in onychophoran segmentation.Development genes and evolution · 2016Article
- Article
- An analysis of segmentation dynamics throughout embryogenesis in the centipede Strigamia maritima.BMC biology · 2013Article
- Evolution of the pair rule gene network: Insights from a centipede.Developmental biology · 2013Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSegmentation is a hallmark of the arthropods; most knowledge about the molecular basis of arthropod segmentation comes from work on the fly Drosophila melanogaster. In this species a hierarchic cascade of segmentation genes subdivides the blastoderm stepwise into single segment wide regions. However, segmentation in the fly is a derived feature since all segments form virtually simultaneously. Conversely, in the vast majority of arthropods the posterior segments form one at a time from a posterior pre-segmental zone. The pair rule genes (PRGs) comprise an important level of the Drosophila segmentation gene cascade and are indeed the first genes that are expressed in typical transverse stripes in the early embryo. Information on expression and function of PRGs outside the insects, however, is scarce.
resultsHere we present the expression of the pair rule gene orthologs in the pill millipede Glomeris marginata (Myriapoda: Diplopoda). We find evidence that these genes are involved in segmentation and that components of the hierarchic interaction of the gene network as found in insects may be conserved. We further provide evidence that segments are formed in a single-segment periodicity rather than in pairs of two like in another myriapod, the centipede Strigamia maritima. Finally we show that decoupling of dorsal and ventral segmentation in Glomeris appears already at the level of the PRGs.
conclusionsAlthough the pair rule gene network is partially conserved among insects and myriapods, some aspects of PRG interaction are, as suggested by expression pattern analysis, convergent, even within the Myriapoda. Conserved expression patterns of PRGs in insects and myriapods, however, may represent ancestral features involved in segmenting the arthropod ancestor.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.