ArticleBMC neurology2011
Sensitivity to heat in MS patients: a factor strongly influencing symptomology--an explorative survey.
Article in BMC neurology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 77 citations in OpenAlex.
- Brain connectivity changes underlying depression and fatigue in relapsing-remitting multiple sclerosis: A systematic review.PloS one · 2024Pooled it
- Home-based Pilates for symptoms of anxiety, depression and fatigue among persons with multiple sclerosis: An 8-week randomized controlled trial.Multiple sclerosis (Houndmills, Basingstoke, England) · 2021Trial
- Trial
- Effects of a Short Physical Exercise Intervention on Patients with Multiple Sclerosis (MS).International journal of molecular sciences · 2015Trial
- A predictive model for corticosteroid response in individual patients with MS relapses.PloS one · 2015Trial
- Climate Change-Mediated Temperature Extremes: Effects on the Immune System and Associations with Immune-Related Diseases.Clinical reviews in allergy & immunology · 2026Review
- The effect of cold-water mouth swilling on thermal perceptions and heat-related symptoms for people with multiple sclerosis exercising in a hot environment.European journal of applied physiology · 2025Article
- A Heat Sensitivity Scale for People with Parkinson's Disease.Movement disorders clinical practice · 2025Article
- Weathering the Pain: Ambient Temperature's Role in Chronic Pain Syndromes.Current pain and headache reports · 2025Review
- Whole-Body Cryostimulation in Multiple Sclerosis: A Scoping Review.Journal of clinical medicine · 2024Article
- Demographic Patterns of MS Patients Using BRISA: An MS-Specific App in Germany.Journal of personalized medicine · 2022Article
- Brain Temperature Influences Intracranial Pressure and Cerebral Perfusion Pressure After Traumatic Brain Injury: A CENTER-TBI Study.Neurocritical care · 2021Article
- Methylome Patterns of Cattle Adaptation to Heat Stress.Frontiers in genetics · 2021Article
- New Strategies for Rehabilitation and Pharmacological Treatment of Fatigue Syndrome in Multiple Sclerosis.Journal of clinical medicine · 2020Review
- Serum Neurofilament Light Chain Levels in Patients With Presymptomatic Multiple Sclerosis.JAMA neurology · 2020Article
- Shedding light on the link between early life sun exposure and risk of multiple sclerosis: results from the EnvIMS Study.International journal of epidemiology · 2019Article
- Association of acute stress with multiple sclerosis onset and relapse in Saudi Arabia.Saudi medical journal · 2019Article
- Burn injury and multiple sclerosis: A retrospective case-control study.Burns : journal of the International Society for Burn Injuries · 2019Article
- Temperature sensitivity in multiple sclerosis: An overview of its impact on sensory and cognitive symptoms.Temperature (Austin, Tex.) · 2018Review
- Fatigue as a symptom or comorbidity of neurological diseases.Nature reviews. Neurology · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMany individuals diagnosed with Multiple Sclerosis (MS) are sensitive to increased body temperature, which has been recognized as correlating with the symptom of fatigue. The need to explore this association has been highlighted. The aim of this study was to investigate the occurrence of heat sensitivity and its relations to disease course, disability, common MS-related symptoms and ongoing immunosuppressive treatments among individuals 65 years of age or younger diagnosed with MS.
methodsA cross-sectional designed survey was undertaken. A questionnaire was sent to MS-patients with an Expanded Disability Status Score (EDSS) in the interval of 0-6.5 and who were between 20 and 65 years of age, living in an eastern region of Sweden (n = 334). Besides occurrence of heat sensitivity (Yes/No) and corresponding questions, the Fatigue Severity Scale (FSS), the MS-related symptom checklist and the Perceived Deficit Questionnaire (PDQ) were included. Data were analysed in relation to data level using Chi-square, Mann Whitney U-test, and Student's t-test. Pearson's and Spearman's correlations were calculated. In the logistic regression analyses (enter) dichotomized MS-symptoms were used as dependent variables, and EDSS, disease-course, time since onset, heat-sensitivity, age and sex (female/male) were independent variables. In the linear regression analyses, enter, mean FSS and summarized PDQ were entered as dependent variables and EDSS, disease-course, time since onset, heat sensitivity, age and sex (female/male) were independent variables.
resultsOf the responding patients (n = 256), 58% reported heat sensitivity. The regression analyses revealed heat sensitivity as a significant factor relating not only to fatigue (p < 0.001), but also to several other common MS symptoms such as pain (p < 0.001), concentration difficulties (p < 0.001), and urination urgency (p = 0.009).
conclusionsHeat sensitivity in MS patients is a key symptom that is highly correlated with disabling symptoms such as fatigue, pain, concentration difficulty and urination urgency.
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Registered trials
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