ArticleEpigenetics & chromatin2011
Distinct influences of tandem repeats and retrotransposons on CENH3 nucleosome positioning.
Article in Epigenetics & chromatin, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
- Evolutionary Balancing of Genetic Consequence and Innovation in Mammals Through Variable Number Tandem Repeats.Genome biology and evolution · 2026Review
- Polymorphic tandem repeats influence cell type-specific gene expression across the human immune landscape.bioRxiv : the preprint server for biology · 2025Article
- High-quality Gossypium hirsutum and Gossypium barbadense genome assemblies reveal the landscape and evolution of centromeres.Plant communications · 2024Article
- Article
- Comparing DNA replication programs reveals large timing shifts at centromeres of endocycling cells in maize roots.PLoS genetics · 2020Article
- Back-spliced RNA from retrotransposon binds to centromere and regulates centromeric chromatin loops in maize.PLoS biology · 2020Article
- Centromere Satellite Repeats Have Undergone Rapid Changes in Polyploid Wheat Subgenomes.The Plant cell · 2019Article
- Stable centromere positioning in diverse sequence contexts of complex and satellite centromeres of maize and wild relatives.Genome biology · 2017Article
- Expressed Centromere Specific Histone 3 (Frontiers in plant science · 2017Article
- The First Rule of Plant Transposable Element Silencing: Location, Location, Location.The Plant cell · 2016Review
- Gene Expression and Chromatin Modifications Associated with Maize Centromeres.G3 (Bethesda, Md.) · 2015Article
- Stable Patterns of CENH3 Occupancy Through Maize Lineages Containing Genetically Similar Centromeres.Genetics · 2015Article
- Accessible DNA and relative depletion of H3K9me2 at maize loci undergoing RNA-directed DNA methylation.The Plant cell · 2014Article
- Differential nuclease sensitivity profiling of chromatin reveals biochemical footprints coupled to gene expression and functional DNA elements in maize.The Plant cell · 2014Article
- 'Memory and molecular turnover,' 30 years after inception.Epigenetics & chromatin · 2014Review
- The CentO satellite confers translational and rotational phasing on cenH3 nucleosomes in rice centromeres.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Changes in nucleosome position at transcriptional start sites of specific genes in Zea mays mediator of paramutation1 mutants.Epigenetics · 2013Article
- Comparative analysis of tandem repeats from hundreds of species reveals unique insights into centromere evolution.Genome biology · 2013Article
- The influence of DNA sequence on epigenome-induced pathologies.Epigenetics & chromatin · 2012Article
- Tripartite organization of centromeric chromatin in budding yeast.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundUnique structural characteristics of centromere chromatin enable it to support assembly of the kinetochore and its associated tensions. The histone H3 variant CENH3 (centromeric histone H3) is viewed as the key element of centromere chromatin and its interaction with centromere DNA is epigenetic in that its localization to centromeres is not sequence-dependent.
resultsIn order to investigate what influence the DNA sequence exerts on CENH3 chromatin structure, we examined CENH3 nucleosome footprints on maize centromere DNA. We found a predominant average nucleosome spacing pattern of roughly 190-bp intervals, which was also the dominant arrangement for nucleosomes genome-wide. For CENH3-containing nucleosomes, distinct modes of nucleosome positioning were evident within that general spacing constraint. Over arrays of the major ~156-bp centromeric satellite sequence (tandem repeat) CentC, nucleosomes were not positioned in register with CentC monomers but in conformity with a striking ~10-bp periodicity of AA/TT dimers within the sequence. In contrast, nucleosomes on a class of centromeric retrotransposon (CRM2) lacked a detectable AA/TT periodicity but exhibited tightly phased positioning.
conclusionsThese data support a model in which general chromatin factors independent of both DNA sequence and CENH3 enforce roughly uniform centromeric nucleosome spacing while allowing flexibility in the mode in which nucleosomes are positioned. In the case of tandem repeat DNA, the natural bending effects related to AA/TT periodicity produce an energetically-favourable arrangement consistent with conformationally rigid nucleosomes and stable chromatin at centromeres.
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