Evidence map›Paper›PMID 21352213›Full record

ArticleHeadache2011

5-HT(1D) receptor immunoreactivity in the sphenopalatine ganglion: implications for the efficacy of triptans in the treatment of autonomic signs associated with cluster headache.

Jason J Ivanusic, Matthew M K Kwok, Andrew H Ahn, Ernest A Jennings

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Headache, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 36 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Review
  4. Review
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Jason J IvanusicFrom the Department of Anatomy and Cell Biology, University of Melbourne, Parkville, Australia (J.J. Ivanusic, M.M.K. Kwok, E.A. Jennings); School of Dentistry James Cook University, Cairns, Queensland, Australia (E.A. Jennings); Department of Neurology, University of Florida College of Medicine, Gainesville, FL, USA (A.H. Ahn).
Matthew M K KwokFrom the Department of Anatomy and Cell Biology, University of Melbourne, Parkville, Australia (J.J. Ivanusic, M.M.K. Kwok, E.A. Jennings); School of Dentistry James Cook University, Cairns, Queensland, Australia (E.A. Jennings); Department of Neurology, University of Florida College of Medicine, Gainesville, FL, USA (A.H. Ahn).
Andrew H AhnFrom the Department of Anatomy and Cell Biology, University of Melbourne, Parkville, Australia (J.J. Ivanusic, M.M.K. Kwok, E.A. Jennings); School of Dentistry James Cook University, Cairns, Queensland, Australia (E.A. Jennings); Department of Neurology, University of Florida College of Medicine, Gainesville, FL, USA (A.H. Ahn).
Ernest A JenningsFrom the Department of Anatomy and Cell Biology, University of Melbourne, Parkville, Australia (J.J. Ivanusic, M.M.K. Kwok, E.A. Jennings); School of Dentistry James Cook University, Cairns, Queensland, Australia (E.A. Jennings); Department of Neurology, University of Florida College of Medicine, Gainesville, FL, USA (A.H. Ahn).
James Cook University · AUUniversity of Melbourne · AU

Funding

Mechanisms of Triptan Action in Migraine and PainK08NS047113 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AHN, ANDREW H · 2004 to 2009
$861k
NINDS NIH HHS K08 NS047113NINDS NIH HHS NS047113
6 · The paper itself

Abstract

objectiveTo determine if 5-HT(1D) receptors are located in the sphenopalatine ganglion.

backgroundWhile the 5-HT(1D) receptor has been described in sensory and sympathetic ganglia in the head, it was not known whether they were also located in parasympathetic ganglia.

methodsWe used retrograde labeling combined with immunohistochemistry to examine 5-HT(1D) receptor immunoreactivity in rat sphenopalatine ganglion neurons that project to the lacrimal gland, nasal mucosa, cerebral vasculature, and trigeminal ganglion.

resultsWe found 5-HT(1D) receptor immunoreactivity in nerve terminals around postganglionic cell bodies within the sphenopalatine ganglion. All 5-HT(1D) -immunoreactive terminals were also immunoreactive for calcitonin gene-related peptide but not vesicular acetylcholine transporter, suggesting that they were sensory and not preganglionic parasympathetic fibers. Our retrograde labeling studies showed that approximately 30% of sphenopalatine ganglion neurons innervating the lacrimal gland, 23% innervating the nasal mucosa, and 39% innervating the trigeminal ganglion were in apparent contact with 5-HT(1D) receptor containing nerve terminals.

conclusionThese data suggest that 5-HT(1D) receptors within primary afferent neurons that innervate the sphenopalatine ganglion are in a position to modulate the excitability of postganglionic parasympathetic neurons that innervate the lacrimal gland and nasal mucosa, as well as the trigeminal ganglion. This has implications for triptan (5-HT(1D) receptor agonist) actions on parasympathetic symptoms in cluster headache.

Indexed as

AnimalsAutonomic Nervous SystemCalcitonin Gene-Related PeptideCluster HeadacheGanglia, ParasympatheticImmunohistochemistryLacrimal ApparatusModels, AnimalNasal MucosaPalate, HardRatsRats, Sprague-DawleyReceptor, Serotonin, 5-HT1DSphenoid BoneTreatment OutcomeTryptaminesCalcitonin Gene-Related PeptideReceptor, Serotonin, 5-HT1DTryptamines

Identifiers

PMID21352213
PMCPMC3073163
OpenAlexW2128838967

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.