ArticleInternational journal of cancer2010
Hospitalizations among children of survivors of childhood and adolescent cancer: a population-based cohort study.
Article in International journal of cancer, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 34 citations in OpenAlex.
- Microdissection testicular sperm extraction after pediatric allogeneic hematopoietic stem cell transplantation: a case series.Bone marrow transplantation · 2024Article
- Parenthood for childhood cancer survivors: unfounded fear of cancer development in offspring and related health behaviors.Frontiers in psychology · 2023Article
- Risk of somatic diseases in offspring of survivors with childhood or adolescent central nervous system tumor in Sweden.International journal of cancer · 2021Article
- Health outcomes in offspring born to survivors of childhood cancers following assisted reproductive technologies.Journal of cancer survivorship : research and practice · 2021Article
- Exposure to Chemotherapy During Childhood or Adulthood and Consequences on Spermatogenesis and Male Fertility.International journal of molecular sciences · 2020Review
- Ambulant health care utilisation among children of childhood cancer survivors in Germany.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2020Article
- Hospitalization rate in offspring of cancer survivors: a national cohort study.Journal of cancer survivorship : research and practice · 2019Article
- Reproductive Function and Outcomes in Female Survivors of Childhood, Adolescent, and Young Adult Cancer: A Review.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2018Review
- Article
- Increased Transgenerational Intestinal Tumorigenesis in Offspring of Ionizing Radiation Exposed Parent APCJournal of Cancer · 2017Article
- Frailty in childhood cancer survivors.Cancer · 2015Review
- Stillbirth, early death and neonatal morbidity among offspring of female cancer survivors.Acta oncologica (Stockholm, Sweden) · 2013Article
- Preconception exposure to mutagens: medical and other exposures to radiation and chemicals.Journal of community genetics · 2012Article
- Evaluation of record linkage between a large healthcare provider and the Utah Population Database.Journal of the American Medical Informatics Association : JAMIA · 2012Article
- Genetic disease in the children of Danish survivors of childhood and adolescent cancer.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2012Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
Curative but potentially mutagenic cancer therapy might lead to untoward disorders and increased hospitalization among the offspring of childhood cancer survivors. Hospitalizations in childhood were evaluated in a population-based cohort of 1,920 offspring of 3,963 childhood cancer survivors, 6,394 offspring of 5,657 siblings and 9,594 population-based comparisons. The Danish Cancer Registry, Central Population Register and National Hospital Register were used to identify study subjects and hospitalizations. The probability for children in the offspring cohorts of being hospitalized before a given age was estimated using the Kaplan-Meier method. Hospitalization rate ratios (HRRs) were calculated using a Cox proportional hazards model with population comparisons as referent. Little differences in hospitalization histories were seen among offspring in the 3 cohorts. HRRs of overall hospitalization was 1.05 (95% CI, 0.98-1.12) for offspring of survivors and 1.01 (95% CI, 0.97-1.05) for offspring of siblings, neither of which was significantly different from that of population comparisons. No significant associations were seen for most of the main diagnostic groups of diseases including infections and perinatal disorders. A 6-fold excess risk of hospitalization for malignant tumors in survivors' offspring, however, could largely be explained by hereditary cancer syndromes, and part of the 2-fold excess hospitalization for benign tumors might similarly be explained by an underlying genetic susceptibility or by increased surveillance of children born to survivors. Assuming that hospitalization is an indicator of multifactorial genetic disease, the findings provide further reassurance that cancer therapies do not confer a high risk of such conditions in offspring born after treatments.
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