ArticleInternational journal of cancer2012
Serum antiglycan antibody detection of nonmucinous ovarian cancers by using a printed glycan array.
Article in International journal of cancer, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 72 citations in OpenAlex.
- The Level of Antibodies to Tumor-Associated Glycans in Gastric Cancer Patients Is Lower than in Healthy Donors and Reduces with Age.International journal of molecular sciences · 2026Article
- Serum antibody screening using glycan arrays.Chemical Society reviews · 2024Review
- The choanoflagellate pore-forming lectin SaroL-1 punches holes in cancer cells by targeting the tumor-related glycosphingolipid Gb3.Communications biology · 2022Article
- Sialic acids in gynecological cancer development and progression: Impact on diagnosis and treatment.International journal of cancer · 2022Review
- Prospects and Challenges of the Study of Anti-Glycan Antibodies and Microbiota for the Monitoring of Gastrointestinal Cancer.International journal of molecular sciences · 2021Review
- Chemoenzymatic modular assembly of O-GalNAc glycans for functional glycomics.Nature communications · 2021Article
- Glycan Array Technology.Advances in biochemical engineering/biotechnology · 2021Article
- Structural Diversities of Lectins Binding to the Glycosphingolipid Gb3.Frontiers in molecular biosciences · 2021Review
- Unique repertoire of anti-carbohydrate antibodies in individual human serum.Scientific reports · 2020Article
- Human Natural Antibodies Recognizing Glycan Galβ1-3GlcNAc (LeInternational journal of molecular sciences · 2020Article
- Emergence and significance of carbohydrate-specific antibodies.Genes and immunity · 2020Review
- Better survival is observed in cervical cancer patients positive for specific anti-glycan antibodies and receiving brachytherapy.Gynecologic oncology · 2020Article
- Exploration of carbohydrate binding behavior and anti-proliferative activities of Arisaema tortuosum lectin.BMC molecular biology · 2019Article
- Multiplex glycan bead array for high throughput and high content analyses of glycan binding proteins.Nature communications · 2018Article
- Tissue glycomics distinguish tumour sites in women with advanced serous adenocarcinoma.Molecular oncology · 2017Article
- Altered (neo-) lacto series glycolipid biosynthesis impairs α2-6 sialylation on N-glycoproteins in ovarian cancer cells.Scientific reports · 2017Article
- Naturally occurring anti-glycan antibodies binding to Globo H-expressing cells identify ovarian cancer patients.Journal of ovarian research · 2017Article
- Development and validation of a Luminex assay for detection of a predictive biomarker for PROSTVAC-VF therapy.PloS one · 2017Article
- Multiplex determination of serological signatures in the sera of colorectal cancer patients using hydrogel biochips.Cancer medicine · 2016Article
- Factors Affecting Anti-Glycan IgG and IgM Repertoires in Human Serum.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
10 authors at 6 institutions in 3 countries.
Funding
Abstract
Epithelial ovarian cancer has the highest mortality rate among gynecological cancers. Altered glycosylation is associated with oncogenic transformation producing tumor-associated carbohydrate antigens. We investigated the potential of natural occurring antiglycan antibodies in the diagnosis of ovarian cancer by using printed glycan array. Antiglycan antibodies bound to 203 chemically synthesized printed glycans were detected via biotin-streptavidin fluorescence system in serum of women with normal operative findings (healthy controls; n = 24) and nonmucinous borderline or ovarian cancer of various FIGO stages (n = 33). Data were validated measuring blood group associated di-, tri and tetrasaccharide antigens on known ABO blood groups. Antiglycan antibodies demonstrated high reproducibility (r(c) > 0.9). Cluster analysis identified repetitive patterns of specific core carbohydrate structures: 11 N-linked glycans, 3 O-linked glycans and 2 glycosphingolipids. Biomarker detection revealed 24 glycans including P(1) (Galα1-4Galβ1-4GlcNAcβ; p < 0.001) significantly discriminating between (low-) malignant tumors and healthy controls. Comparable sensitivity and specificity with tumor marker CA125 was achieved by a panel of multivariate selected and linear combined antiglycan antibody signals (79.2 and 84.8%, respectively). Our findings demonstrate the potential of glycan arrays in the development of a new generation of biomarkers for ovarian cancer.
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Registered trials
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