ArticleWorld journal of gastroenterology2011
Effects of intestinal mucosal blood flow and motility on intestinal mucosa.
Article in World journal of gastroenterology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 33 citations in OpenAlex.
- Diversity of intestinal microbiota and inflammatory cytokines after severe trauma.Scientific reports · 2025Article
- Stroke Alters the Function of Enteric Neurons to Impair Smooth Muscle Relaxation and Dysregulates Gut Transit.Journal of the American Heart Association · 2024Article
- A novel beneficial role of humanin on intestinal apoptosis and dysmotility in a rat model of ischemia reperfusion injury.Pflugers Archiv : European journal of physiology · 2023Article
- Bidirectional Brain-gut-microbiota Axis in increased intestinal permeability induced by central nervous system injury.CNS neuroscience & therapeutics · 2020Review
- Gastrointestinal transit time and heart rate variability in patients with mild acquired brain injury.PeerJ · 2018Article
- Comparison between tocotrienol and omeprazole on gastric growth factors in stress-exposed rats.World journal of gastroenterology · 2017Article
- Preventive Effects of Tocotrienol on Stress-Induced Gastric Mucosal Lesions and Its Relation to Oxidative and Inflammatory Biomarkers.PloS one · 2015Article
- Article
- Alterations in enterocyte mitochondrial respiratory function and enzyme activities in gastrointestinal dysfunction following brain injury.World journal of gastroenterology · 2014Article
- Effects of traumatic brain injury on intestinal contractility.Neurogastroenterology and motility · 2013Article
- Tocotrienol Attenuates Stress-Induced Gastric Lesions via Activation of Prostaglandin and Upregulation of COX-1 mRNA.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Feeding administration of Daikenchuto suppresses colitis induced by naive CD4+ T cell transfer into SCID mice.Digestive diseases and sciences · 2012Article
- Chronic bile duct hyperplasia is a chronic graft dysfunction following liver transplantation.World journal of gastroenterology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the role of intestinal mucosal blood flow (IMBF) and motility in the damage of intestinal mucosal barrier in rats with traumatic brain injury.
methodsSixty-four healthy male Wistar rats were divided randomly into two groups: traumatic brain injury (TBI) group (n=32), rats with traumatic brain injury; and control group (n=32), rats with sham-operation. Each group was divided into four subgroups (n=8) as 6, 12, 24 and 48 h after operation. Intestinal motility was measured by the propulsion ratio of a semi-solid colored marker (carbon-ink). IMBF was measured with the laser-Doppler technique. Endotoxin and D-xylose levels in plasma were measured to evaluate the change of intestinal mucosal barrier function following TBI.
resultsThe level of endotoxin was significantly higher in TBI group than in the control group at each time point (0.382±0.014 EU/mL vs 0.102±0.007 EU/mL, 0.466±0.018 EU/mL vs 0.114±0.021 EU/mL, 0.478±0.029 EU/mL vs 0.112±0.018 EU/mL and 0.412±0.036 EU/mL vs 0.108±0.011 EU/mL, P<0.05). D-xylose concentrations in plasma in TBI group were significantly higher than in the control group (6.68±2.37 mmol/L vs 3.66±1.07 mmol/L, 8.51±2.69 mmol /L vs 3.15±0.95 mmol/L, 11.68±3.24 mmol/L vs 3.78±1.12 mmol/L and 10.23±2.83 mmol/L vs 3.34±1.23 mmol/ L, P<0.05). The IMBF in TBI group was significantly lower than that in the control group (38.5±2.8 PU vs 45.6±4.6 PU, 25.2±3.1 PU vs 48.2±5.3 PU, 21.5±2.7 PU vs 44.9±2.8 PU, 29. 4±3.8 PU vs 46.7±3.2 PU) (P<0.05). Significant decelerations of intestinal propulsion ratio in TBI groups were found compared with the control group (0.48%±0.06% vs 0.62%±0.03%, 0.37%±0.05% vs 0.64%±0.01%, 0.39%±0.07% vs 0.63%±0.05% and 0.46%±0.03% vs 0.65%±0.02%) (P<0.05).
conclusionThe intestinal mucosal permeability is increased obviously in TBI rats. Decrease of intestinal motility and IMBF occur early in TBI, both are important pathogenic factors for stress-related damage of the intestinal mucosal barrier in TBI.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.