ArticleWorld journal of gastroenterology2011
Analysis of the urinary peptidome associated with Helicobacter pylori infection.
Article in World journal of gastroenterology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Recent progress in mass spectrometry-based urinary proteomics.Clinical proteomics · 2024Review
- Urinary Peptides Associated Closely with Gestational Diabetes Mellitus.Disease markers · 2020Article
- The Difference Quantity of Urinary Peptides between Two Groups of Type 2 Diabetic Patients with or without Coronary Artery Disease.International journal of endocrinology · 2015Article
- Detection of ricin intoxication in mice using serum peptide profiling by MALDI-TOF/MS.International journal of molecular sciences · 2012Article
- Detection and diagnostic applicability of human urinary kininogen in kala-azar patients.Parasitology research · 2012Article
- Detection of murine toxoplasmosis using magnetic bead-based serum peptide profiling by MALDI-TOF MS.Vector borne and zoonotic diseases (Larchmont, N.Y.) · 2012Article
- Detection of Leishmania donovani infection using magnetic beads-based serum peptide profiling by MALDI-TOF MS in mice model.Parasitology research · 2012Article
- Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the relationship between urinary peptide changes and Helicobacter pylori (H. pylori) infection using urinary peptidome profiling.
methodsThe study was performed in volunteers (n=137) who gave informed consent. Urinary peptides were enriched by magnetic beads based weak cation exchange chromatography and spectrums acquired by matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry (MS). ClinProTools bioinformatics software was used for statistical analysis and the recognition of peptide patterns. The marker peptides were identified by LTQ Obitrap XL tandem MS.
resultsApproximately 50 proteins or peptides which loaded onto the magnetic beads were detected by MALDI-TOF MS. By optimizing the parameters of the model, the Genetic Algorithm model had good recognition capability (97%) and positive predictive value (94%). Based on the model, 2 markers with molecular masses of 6788 and 1912 Da were found that differentiated between H. pylori positive and negative volunteers. The m/z 1912 sequence was parsed as SKQFTSSTSYNRGDSTF. The peptide was identified as isoform 1 of the fibrinogen α chain precursor, whose concentration in urine was markedly higher in H. pylori infected volunteers than in H. pylori non-infected ones.
conclusionThe appearance of urinary fibrinogen degradation products is caused by an active H. pylori-induced process.
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