ArticleBiotechnology research international2011
Biosynthesis and Virulent Behavior of Lipids Produced by Mycobacterium tuberculosis: LAM and Cord Factor: An Overview.
Article in Biotechnology research international, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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Who cites it
20 citing papers in PubMed, 48 citations in OpenAlex.
- Protein-Mediated Virulence in Mycobacterium tuberculosis.Advances in experimental medicine and biology · 2026Review
- Review on Current Research on Biosynthesis of Biosurfactants and the Regulation Influenced by Metal Ions.Journal of microbiology and biotechnology · 2025Review
- Article
- Host- and Age-Dependent Transcriptional Changes inInternational journal of molecular sciences · 2022Article
- The Regulation of ManLAM-Related Gene Expression inInfection and drug resistance · 2022Article
- In Vitro Models for Studying Respiratory Host-Pathogen Interactions.Advanced biology · 2021Review
- Trehalose Recycling Promotes Energy-Efficient Biosynthesis of the Mycobacterial Cell Envelope.mBio · 2021Article
- Adhesion molecules facilitate host-pathogen interaction & mediateThe Indian journal of medical research · 2019Review
- Underestimated Manipulative Roles ofFrontiers in immunology · 2019Review
- Triacylglycerol: nourishing molecule in endurance of Mycobacterium tuberculosis.Journal of biosciences · 2018Review
- Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2018Review
- Comparative lipidomics of drug sensitive and resistant3 Biotech · 2017Article
- Biochemical characterization of PE_PGRS61 family protein ofIranian journal of basic medical sciences · 2016Article
- Bacterial iron-sulfur cluster sensors in mammalian pathogens.Metallomics : integrated biometal science · 2015Review
- Evaluation of antigen-specific immunoglobulin g responses in pulmonary tuberculosis patients and contacts.Journal of clinical microbiology · 2015Article
- The mycobacterial cell envelope-lipids.Cold Spring Harbor perspectives in medicine · 2014Review
- Rapid diagnosis of pulmonary tuberculosis.The Pan African medical journal · 2014Article
- Structural determination and Toll-like receptor 2-dependent proinflammatory activity of dimycolyl-diarabino-glycerol from Mycobacterium marinum.The Journal of biological chemistry · 2012Article
- PET/CT imaging ofClinical and translational imagingReview
- Revisiting the Rich's formula: an update about granulomas in human tuberculosis.The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious DiseasesReview
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mycobacterium tuberculosis is the causative agent of tuberculosis disease, which has developed a myriad of exceptional features contributing to its survival within the hostile environment of host cell. Unique cell wall structure with high lipid content plays an imperative role in the pathogenicity of mycobacteria. Cell wall components of MTB such as lipoarabinomannan and Trehalose dimycolate (cord factor) are virulent in nature apart from its virulence genes. Virulent effect of these factors on host cells reduces host cell immunity. LAM has been known to inhibit phagosome maturation by inhibiting the Ca(2+)/calmodulin phosphatidyl inositol-3-kinase hvps34 pathways. Moreover, TDM (Trehalose dimycolate) also inhibits fusion between phospholipid vesicles and migration of polymorphonuclear neutrophils. The objective of this paper is to understand the virulence of LAM and cord factor on host cell which might be helpful to design an effective drug against tuberculosis.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.