Evidence map›Paper›PMID 21350578›Full record

ReviewNature reviews. Immunology2011

DCs and NK cells: critical effectors in the immune response to HIV-1.

Marcus Altfeld, Lena Fadda, Davor Frleta, Nina Bhardwaj

Abstract readReview
In one paragraph

Review in Nature reviews. Immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 107 papers.

0numbers the graph read from it
0cells of the map it votes in
107citing papers in PubMed
12.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

107 citing papers in PubMed, 200 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Trial
  4. Article
  5. CXCR6Frontiers in immunology · 2026
    Article
  6. Article
  7. Review
  8. Review
  9. Immunostimulatory Pickering emulsion for oral vaccine delivery.International journal of pharmaceutics · 2025
    Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Natural Bio-Compounds fromAntioxidants (Basel, Switzerland) · 2023
    Review
  15. Article
  16. Article
  17. Review
  18. Review
  19. IL-18 Responsiveness Defines Limitations in Immune Help for Specialized FcRγJournal of immunology (Baltimore, Md. : 1950) · 2020
    Article
  20. Regulation of NK-Cell Function by HLA Class II.Frontiers in cellular and infection microbiology · 2020
    Article

47 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Marcus AltfeldRagon Institute of MGH, MIT and Harvard, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA. maltfeld@partners.org
Lena Fadda
Davor Frleta
Nina Bhardwaj
NYU Langone Health · USRagon Institute of MGH, MIT and Harvard · US

Funding

Viral Sequencing CoreU19AI067854 · NIAID · DUKE UNIVERSITY · PI HAYNES, BARTON F. · 2006 to 2011
$290.5M
Recognition of HIV-1 by Innate Immunity Receptors during Primary InfectionP01AI074415 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI ALLEN, TODD M · 2008 to 2013
$17.3M
Modulating anti-HIV immunity by plasmacytoid dendritic cellsR01AI081848 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BHARDWAJ, NINA · 2010 to 2021
$4.5M
Induction of Immunity by Non-Replicating HIV-1R37AI044628 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BHARDWAJ, NINA · 2004 to 2014
$4.2M
TLR-mediated gender differences in HIV-1 pathogenesisR01AI078784 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI ALTFELD, MARCUS · 2010 to 2013
$1.7M
NIAID NIH HHS P01 AI074415NIAID NIH HHS R01 AI078784NIAID NIH HHS R01 AI081848NIAID NIH HHS R37 AI044628NIAID NIH HHS U19 AI067854
6 · The paper itself

Abstract

Dendritic cells (DCs) and natural killer (NK) cells have central roles in antiviral immunity by shaping the quality of the adaptive immune response to viruses and by mediating direct antiviral activity. HIV-1 infection is characterized by a severe dysregulation of the antiviral immune response that starts during early infection. This Review describes recent insights into how HIV-1 infection affects DC and NK cell function, and the roles of these innate immune cells in HIV-1 pathogenesis. The importance of understanding DC and NK cell crosstalk during HIV infection for the development of effective antiviral strategies is also discussed.

Indexed as

Adaptive ImmunityAIDS VaccinesAnimalsAntigen PresentationAntigens, CDAutophagyCell Adhesion MoleculesCell CommunicationDC-Specific ICAM-3 Grabbing NonintegrinDendritic CellsFemaleHaplorhiniHIV-1HIV AntigensHIV Envelope Protein gp120HIV InfectionsAIDS VaccinesAntigens, CDCD207 protein, humanCell Adhesion MoleculesDC-Specific ICAM-3 Grabbing Nonintegringp120 protein, Human immunodeficiency virus 1HIV AntigensHIV Envelope Protein gp120Lectins, C-TypeMannose-Binding LectinsReceptors, Cell SurfaceReceptors, HIVReceptors, KIRTLR8 protein, humanToll-Like Receptor 8

Identifiers

PMID21350578
PMCPMC3278081
OpenAlexW2084384009

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.