ArticleObesity (Silver Spring, Md.)2012
Relations of circulating resistin and adiponectin and cardiac structure and function: the Framingham Offspring Study.
Article in Obesity (Silver Spring, Md.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 69 citations in OpenAlex.
- Type 2 Diabetes Mellitus Remission, Dream or Reality? A Narrative Review of Current Evidence and Integrated Care Strategies.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2025Review
- Cardiac-to-adipose axis in metabolic homeostasis and diseases: special instructions from the heart.Cell & bioscience · 2023Review
- Adiponectin and metabolic cardiovascular diseases: Therapeutic opportunities and challenges.Genes & diseases · 2023Review
- The role of obesity-related cardiovascular remodelling in mediating incident cardiovascular outcomes: a population-based observational study.European heart journal. Cardiovascular Imaging · 2023Observational
- Biomarkers in Acute Heart Failure Syndromes: An Update.Current cardiology reviews · 2022Review
- Environmental Contaminants Acting as Endocrine Disruptors Modulate Atherogenic Processes: New Risk Factors for Cardiovascular Diseases in Women?Biomolecules · 2021Review
- Abnormal transaminase and lipid profiles in coexisting diseases in patients with fatty liver: a population study in Sichuan.Bioscience reports · 2021Article
- Crossroads between Estrogen Loss, Obesity, and Heart Failure with Preserved Ejection Fraction.Arquivos brasileiros de cardiologia · 2021Review
- Obesity cardiomyopathy: evidence, mechanisms, and therapeutic implications.Physiological reviews · 2021Review
- Association of Adiponectin, Leptin and Resistin Plasma Concentrations with Echocardiographic Parameters in Patients with Coronary Artery Disease.Diagnostics (Basel, Switzerland) · 2021Article
- Seipin Deficiency Accelerates Heart Failure Due to Calcium Handling Abnormalities and Endoplasmic Reticulum Stress in Mice.Frontiers in cardiovascular medicine · 2021Article
- The Significance of the Effect of Visceral Adiposity on Left Ventricular Diastolic Function in the General Population.Scientific reports · 2019Article
- Association of Circulating Adipokines With Echocardiographic Measures of Cardiac Structure and Function in a Community-Based Cohort.Journal of the American Heart Association · 2018Article
- Loss of Cardio-Protective Effects at the CDH13 Locus Due to Gene-Sleep Interaction: The BCAMS Study.EBioMedicine · 2018Article
- Ambient air pollution, adipokines, and glucose homeostasis: The Framingham Heart Study.Environment international · 2018Article
- Weight History and Subclinical Myocardial Damage.Clinical chemistry · 2018Article
- Indexed Left Atrial Adipose Tissue Area Is Associated With Severity of Atrial Fibrillation and Atrial Fibrillation Recurrence Among Patients Undergoing Catheter Ablation.Frontiers in cardiovascular medicine · 2018Article
- Serum HBV surface antigen positivity is associated with low prevalence of metabolic syndrome: A meta-analysis.PloS one · 2017Article
- Obesity and Subtypes of Incident Cardiovascular Disease.Journal of the American Heart Association · 2016Observational
- Longitudinal associations between adiponectin and cardiac structure differ by hypertensive status: Coronary Artery Risk Development in Young Adults.Cardiovascular endocrinology · 2016Article
Corrections and comments
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Authors and funding
8 authors at 6 institutions in 2 countries.
Funding
Abstract
Obesity is associated with pathological cardiac remodeling and risk of heart failure (HF). Adipocytokines (ADKs) may mediate the increased risk of cardiovascular disease associated with excess adiposity. Yet data relating ADKs to cardiac remodeling phenotypes are sparse. We related two circulating ADKs, resistin and adiponectin, to three important echocardiographic markers of cardiac remodeling, left ventricular mass (LVM), left atrial diameter (LAD), and LV fractional shortening (LVFS) in 2,615 participants (mean age 61 years, 55% women) in the Framingham Offspring Study. Adiponectin concentrations were inversely related to LVM in multivariable linear regression models adjusting for key clinical correlates including BMI (regression coefficient per s.d.-increment in ln-adiponectin = -3.37, P = 0.02; P for trend across quartiles = 0.02). Adiponectin was not associated with LAD or LVFS (P > 0.56). Resistin concentrations were inversely related to LVFS (regression coefficient per s.d.-increment in ln-resistin = -0.01, P = 0.03; P for trend across quartiles = 0.04). Resistin was not associated with LVM or LAD (P > 0.05). In our moderate-sized, community-based sample, higher circulating concentrations of adiponectin and resistin were associated with lower LVM and lower LVFS, respectively. In conclusion, these associations identify potential mechanisms by which excess adiposity may mediate adverse cardiac remodeling and HF risk.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.