ArticleJournal of acquired immune deficiency syndromes (1999)2011
Predictors of survival after a diagnosis of non-Hodgkin lymphoma in a resource-limited setting: a retrospective study on the impact of HIV infection and its treatment.
Article in Journal of acquired immune deficiency syndromes (1999), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Impact of Antiretroviral Therapy on Cancer Treatment Outcomes among People Living with HIV in Low- and Middle-Income Countries: a Systematic Review.Current HIV/AIDS reports · 2021Pooled it
- Safety and efficacy of rituximab in patients with diffuse large B-cell lymphoma in Malawi: a prospective, single-arm, non-randomised phase 1/2 clinical trial.The Lancet. Global health · 2021Trial
- Treatment adherence, survival outcomes and barriers to care of non-Hodgkin lymphoma in Northwest Ethiopia: a mixed-methods study.BMJ open · 2026Article
- Article
- Lymphoma in Sub-Saharan Africa: a scoping review of the epidemiology, treatment challenges, and patient pathways.Cancer causes & control : CCC · 2025Article
- Global view of haematolymphoid tumor classifications and their application in low- and middle-income countries.Histopathology · 2025Review
- Guideline Concordance of Treatment and Outcomes Among Adult Non-Hodgkin Lymphoma Patients in Sub-Saharan Africa: A Multinational, Population-Based Cohort.The oncologist · 2023Article
- Clinical and Therapeutic Profile of Non-Hodgkin's Lymphoma: A Retrospective Study From a Najran Oncology Center.Cureus · 2023Article
- Virologic Nonsuppression Among Patients With HIV Newly Diagnosed With Cancer at Uganda Cancer Institute: A Cross-Sectional Study.JCO global oncology · 2023Article
- Article
- Outcomes of treatment with CHOP and EPOCH in patients with HIV associated NHL in a low resource setting.BMC cancer · 2020Article
- Challenges of HIV Lymphoma Clinical Trials in Africa: Lessons From the AIDS Malignancy Consortium 068 Study.JCO global oncology · 2020Article
- Real-world use of chemotherapy for Kaposi's sarcoma in a large community-based HIV primary care system in Kenya.BMC cancer · 2020Article
- Survival of HIV-infected patients with high-grade non-Hodgkin's lymphomas: A retrospective study of experiences in Zimbabwe.PloS one · 2020Article
- HIV-Related Skin Disease in the Era of Antiretroviral Therapy: Recognition and Management.American journal of clinical dermatology · 2019Review
- Mature outcomes and prognostic indices in diffuse large B-cell lymphoma in Malawi: a prospective cohort.British journal of haematology · 2019Observational
- Palliative care guidelines for the management of HIV-infected people in South Africa.Southern African journal of HIV medicine · 2019Article
- Impact of HIV Infection on the Clinical Presentation and Survival of Non-Hodgkin Lymphoma: A Prospective Observational Study From Botswana.Journal of global oncology · 2018Observational
- Evaluating Antiretroviral Therapy Initiation in HIV-Associated Malignancy: Is There Enough Evidence to Inform Clinical Guidelines?Journal of the National Comprehensive Cancer Network : JNCCN · 2018Article
- Lymphoma and Pathology in Sub-Saharan Africa: Current Approaches and Future Directions.Clinics in laboratory medicine · 2018Review
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
objectiveWe examined factors associated with survival among patients with newly diagnosed non-Hodgkin lymphoma (NHL) in Uganda.
methodsInformation was abstracted from medical records for all NHL patients >13 years of age at the Uganda Cancer Institute between January 2004 and August 2008. Cox proportional hazard models were used to identify predictors of NHL survival.
resultsOne hundred sixty patients with NHL were identified; 51 (31.9%) were known to be HIV positive. Overall, 154 patients had records sufficient for further analysis. The median person-time observed was 104 days (interquartile range 26-222). Median survival after presentation among those whose mortality status was confirmed was 61 days (interquartile range 25-203). HIV-positive patients receiving antiretroviral therapy had survival rates approximating those of HIV-negative persons, but the adjusted hazard of death was significantly elevated among HIV-positive patients not receiving antiretroviral therapy [adjusted hazard ratio (HR) 8.99, P < 0.001] compared with HIV-negative patients. Both B-symptoms (HR 2.08, P = 0.05) and female gender (HR 1.72, P = 0.05) were associated with higher mortality.
conclusionsIn Uganda, overall survival of NHL patients is poor, and predictors of survival differed from those described in resource-rich regions. HIV is a common comorbidity to NHL, and its lack of treatment was among the strongest predictors of mortality. Strategies are needed for optimal management of HIV-infected individuals with cancer in resource-limited settings.
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