ArticleDevelopment (Cambridge, England)2011
Drosophila hedgehog signaling and engrailed-runt mutual repression direct midline glia to alternative ensheathing and non-ensheathing fates.
Article in Development (Cambridge, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 21 citations in OpenAlex.
- Engrailed transcription factors direct excitatory cerebellar neuron diversity and survival.Development (Cambridge, England) · 2024Article
- Patched-Related Is Required for Proper Development of EmbryonicFrontiers in neuroscience · 2022Article
- Early lineage segregation of the retinal basal glia in the Drosophila eye disc.Scientific reports · 2020Article
- Review
- Origins of glial cell populations in the insect nervous system.Current opinion in insect science · 2016Review
- Chromatin profiling of Drosophila CNS subpopulations identifies active transcriptional enhancers.Development (Cambridge, England) · 2016Article
- Article
- The Hedgehog Signalling Pathway in Cell Migration and Guidance: What We Have Learned from Drosophila melanogaster.Cancers · 2015Review
- Enhancer diversity and the control of a simple pattern of Drosophila CNS midline cell expression.Developmental biology · 2014Article
- Coordinated repression and activation of two transcriptional programs stabilizes cell fate during myogenesis.Development (Cambridge, England) · 2014Article
- Article
- Probing the enigma: unraveling glial cell biology in invertebrates.Current opinion in neurobiology · 2013Review
- Formation and specification of a Drosophila dopaminergic precursor cell.Development (Cambridge, England) · 2012Article
- Time-lapse imaging reveals stereotypical patterns of Drosophila midline glial migration.Developmental biology · 2012Article
- Morphological characterization of the entire interneuron population reveals principles of neuromere organization in the ventral nerve cord of Drosophila.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Mastermind mutations generate a unique constellation of midline cells within the Drosophila CNS.PloS one · 2011Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The Drosophila CNS contains a variety of glia, including highly specialized glia that reside at the CNS midline and functionally resemble the midline floor plate glia of the vertebrate spinal cord. Both insect and vertebrate midline glia play important roles in ensheathing axons that cross the midline and secreting signals that control a variety of developmental processes. The Drosophila midline glia consist of two spatially and functionally distinct populations. The anterior midline glia (AMG) are ensheathing glia that migrate, surround and send processes into the axon commissures. By contrast, the posterior midline glia (PMG) are non-ensheathing glia. Together, the Notch and hedgehog signaling pathways generate AMG and PMG from midline neural precursors. Notch signaling is required for midline glial formation and for transcription of a core set of midline glial-expressed genes. The Hedgehog morphogen is secreted from ectodermal cells adjacent to the CNS midline and directs a subset of midline glia to become PMG. Two transcription factor genes, runt and engrailed, play important roles in AMG and PMG development. The runt gene is expressed in AMG, represses engrailed and maintains AMG gene expression. The engrailed gene is expressed in PMG, represses runt and maintains PMG gene expression. In addition, engrailed can direct midline glia to a PMG-like non-ensheathing fate. Thus, two signaling pathways and runt-engrailed mutual repression initiate and maintain two distinct populations of midline glia that differ functionally in gene expression, glial migration, axon ensheathment, process extension and patterns of apoptosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.