ArticleDevelopment (Cambridge, England)2011
Ral GTPase promotes asymmetric Notch activation in the Drosophila eye in response to Frizzled/PCP signaling by repressing ligand-independent receptor activation.
Article in Development (Cambridge, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 25 citations in OpenAlex.
- Regulation of Drosophila brain development and organ growth by the Minibrain/Rala signaling network.G3 (Bethesda, Md.) · 2024Article
- Planar Cell Polarity Signaling: Coordinated Crosstalk for Cell Orientation.Journal of developmental biology · 2024Review
- How do the Fat-Dachsous and core planar polarity pathways act together and independently to coordinate polarized cell behaviours?Open biology · 2021Review
- Ral function in muscle is required for flight maintenance inSmall GTPases · 2020Article
- Article
- Past1 Modulates Drosophila Eye Development.PloS one · 2017Article
- Cullin-4 regulates Wingless and JNK signaling-mediated cell death in the Drosophila eye.Cell death & disease · 2016Article
- Ral GTPase and the exocyst regulate autophagy in a tissue-specific manner.EMBO reports · 2016Article
- Ligand-Independent Mechanisms of Notch Activity.Trends in cell biology · 2015Review
- Article
- Planar cell polarity controls directional Notch signaling in the Drosophila leg.Development (Cambridge, England) · 2012Article
- The frizzled/stan pathway and planar cell polarity in the Drosophila wing.Current topics in developmental biology · 2012Review
- Article
- The planar cell polarity pathway in vertebrate epidermal development, homeostasis and repair.OrganogenesisArticle
- A big new job for small GTPases.Small GTPasesArticle
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Ral is a small Ras-like GTPase that regulates membrane trafficking and signaling. Here, we show that in response to planar cell polarity (PCP) signals, Ral modulates asymmetric Notch signaling in the Drosophila eye. Specification of the initially equivalent R3/R4 photoreceptor precursor cells in each developing ommatidium occurs in response to a gradient of Frizzled (Fz) signaling. The cell with the most Fz signal (R3) activates the Notch receptor in the adjacent cell (R4) via the ligand Delta, resulting in R3/R4 cell determination and their asymmetric positions within the ommatidium. Two mechanisms have been proposed for ensuring that the cell with the most Fz activation sends the Delta signal: Fz-dependent transcriptional upregulation in R3 of genes that promote Delta signaling, and direct blockage of Notch receptor activation in R3 by localization of an activated Fz/Disheveled protein complex to the side of the plasma membrane adjacent to R4. Here, we discover a distinct mechanism for biasing the direction of Notch signaling that depends on Ral. Using genetic experiments in vivo, we show that, in direct response to Fz signaling, Ral transcription is upregulated in R3, and Ral represses ligand-independent activation of Notch in R3. Thus, prevention of ligand-independent Notch activation is not simply a constitutive process, but is a target for regulation by Ral during cell fate specification and pattern formation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.