ArticleCell calcium2011
Regulation of cardiac Ca(2+) channel by extracellular Na(+).
Article in Cell calcium, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 35 citations in OpenAlex.
- Long-Term Clinical Relevance of Hyponatremia Identified During Acute Phase of Myocardial Infarction.Journal of clinical medicine · 2025Article
- Changes in serum sodium concentration during hemodialysis is a predictor of mortality and cardio-cerebrovascular event.Renal failure · 2024Article
- Unlocking the secrets of electrolytes: the prognostic value of sodium-to-chloride ratio in intensive care unit patients with myocardial infarction.BMC cardiovascular disorders · 2024Article
- Association of serum sodium levels with fractures and mortality in patients undergoing maintenance hemodialysis.Journal of nephrology · 2024Article
- Clinical characteristics and outcomes of maintenance hemodialysis patients with COVID-19 during the Omicron wave of the pandemic in Beijing: a single center retrospective study.BMC nephrology · 2024Article
- Identification of independent risk factors for hypoalbuminemia in patients with CKD stages 3 and 4: the construction of a nomogram.Frontiers in nutrition · 2024Article
- The association of hyponatremia and clinical outcomes in patients with acute myocardial infarction: a cross-sectional study.BMC cardiovascular disorders · 2022Article
- Preoperative hyponatremia predicts complications in older patients undergoing digestive tract surgery: a propensity score matching analysis.European geriatric medicine · 2022Article
- Sodium-based osmotherapy for hyponatremia in acute decompensated heart failure.Heart failure reviews · 2022Review
- Hyponatremia in the Dialysis Population.Kidney international reports · 2019Review
- Sodium levels during hospitalization with acute myocardial infarction are markers of in-hospital mortality: Soroka acute myocardial infarction II (SAMI-II) project.Clinical research in cardiology : official journal of the German Cardiac Society · 2018Article
- Serum sodium and mortality in a national peritoneal dialysis cohort.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2017Observational
- Pre-dialysis serum sodium and mortality in a national incident hemodialysis cohort.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2016Observational
- Current treatment practice and outcomes. Report of the hyponatremia registry.Kidney international · 2015Article
- Hyponatremia, mineral metabolism, and mortality in incident maintenance hemodialysis patients: a cohort study.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2013Article
- Outcomes of correcting hyponatremia in patients with myocardial infarction.Clinical research in cardiology : official journal of the German Cardiac Society · 2013Article
- Effects of fluorine-containing opener of ATP-sensitive potassium channels, pinacidil-derivative flocalin, on cardiac voltage-gated sodium and calcium channels.Naunyn-Schmiedeberg's archives of pharmacology · 2012Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
Hyponatremia is a predictor of poor cardiovascular outcomes during acute myocardial infarction and in the setting of preexisting heart failure [1]. There are no definitive mechanisms as to how hyponatremia suppresses cardiac function. In this report we provide evidence for direct down-regulation of Ca(2+) channel current in response to low serum Na(+). In voltage-clamped rat ventricular myocytes or HEK 293 cells expressing the L-type Ca(2+) channel, a 15mM drop in extracellular Na(+) suppressed the Ca(2+) current by ∼15%; with maximal suppression of ∼30% when Na(+) levels were reduced to 100mM or less. The suppressive effects of low Na(+) on I(Ca), in part, depended on the substituting monovalent species (Li(+), Cs(+), TEA(+)), but were independent of phosphorylation state of the channel and possible influx of Ca(2+) on Na(+)/Ca(2+) exchanger. Acidification sensitized the Ca(2+) channel current to Na(+) withdrawal. Collectively our data suggest that Na(+) and H(+) may interact with regulatory site(s) at the outer recesses of the Ca(2+) channel pore thereby directly modulating the electro-diffusion of the permeating divalents (Ca(2+), Ba(2+)).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.