Evidence map›Paper›PMID 21349208›Full record

ReviewGenome biology2011

The properties and applications of single-molecule DNA sequencing.

John F Thompson, Patrice M Milos

Abstract readReview
In one paragraph

Review in Genome biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed.

  1. Article
  2. Glycan Sequencing, A Brief Primer.Glycoscience & therapy · 2026
    Article
  3. Functional Characterization ofAnimals : an open access journal from MDPI · 2025
    Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Rapid and qualitative identification of SARS-CoV-2 mutations associated with variants of concern using a multiplex RT-PCR assay coupled with melting analysis.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2022
    Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Next-Generation Sequencing in Blood Group Genomics: State of the Art and Perspectives.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2020
    Article
  14. Cell Separations and Sorting.Analytical chemistry · 2020
    Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

John F ThompsonHelicos BioSciences Corporation, Building 200LL, One Kendall Square, Cambridge, MA 02139, USA. jthompson@helicosbio.com
Patrice M Milos

Funding

Providing the $1000 genome via improved single molecule sequencingRC2HG005598 · NHGRI · HELICOS BIOSCIENCE CORPORATION · PI THOMPSON, JOHN FENTON · 2009 to 2010
$2.9M
High Accuracy Single Molecule DNA Sequencing by SynthesisR01HG004144 · NHGRI · HELICOS BIOSCIENCE CORPORATION · PI THOMPSON, JOHN FENTON · 2006 to 2008
$2.0M
NHGRI NIH HHS R01 HG004144NHGRI NIH HHS RC2 HG005598
6 · The paper itself

Abstract

Single-molecule sequencing enables DNA or RNA to be sequenced directly from biological samples, making it well-suited for diagnostic and clinical applications. Here we review the properties and applications of this rapidly evolving and promising technology.

Indexed as

AnimalsDNADNA-Directed DNA PolymeraseDNA PrimersFluorescenceFluorescence Resonance Energy TransferGenomicsHigh-Throughput Nucleotide SequencingHumansMolecular ProbesNanotechnologyQuantum DotsRNASequence Analysis, DNADNADNA-Directed DNA PolymeraseDNA PrimersMolecular ProbesRNA

Identifiers

PMID21349208
PMCPMC3188791

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.