Evidence map›Paper›PMID 21348520›Full record

ArticleJournal of the American Chemical Society2011

Single-step charge transport through DNA over long distances.

Joseph C Genereux, Stephanie M Wuerth, Jacqueline K Barton

Open access · greenAbstract read
In one paragraph

Article in Journal of the American Chemical Society, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
6.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 56 citations in OpenAlex.

  1. Article
  2. The Dynamics of Hole Transfer in DNA.Molecules (Basel, Switzerland) · 2019
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Impact of a single base pair substitution on the charge transfer rate along short DNA hairpins.Proceedings of the National Academy of Sciences of the United States of America · 2013
    Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Joseph C GenereuxDivision of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, United States.
Stephanie M Wuerth
Jacqueline K Barton
California Institute of Technology · US

Funding

DNA-MEDIATED ELECTRON TRANSFER REACTIONSR01GM049216 · NIGMS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI BARTON, JACQUELINE K · 1993 to 2012
$4.0M
NIGMS NIH HHS GM49216NIGMS NIH HHS R01 GM049216
6 · The paper itself

Abstract

Quantum yields for charge transport across adenine tracts of increasing length have been measured by monitoring hole transport in synthetic oligonucleotides between photoexcited 2-aminopurine, a fluorescent analogue of adenine, and N(2)-cyclopropyl guanine. Using fluorescence quenching, a measure of hole injection, and hole trapping by the cyclopropyl guanine derivative, we separate the individual contributions of single- and multistep channels to DNA charge transport and find that with 7 or 8 intervening adenines the charge transport is a coherent, single-step process. Moreover, a transition occurs from multistep to single-step charge transport with increasing donor/acceptor separation, opposite to that generally observed in molecular wires. These results establish that coherent transport through DNA occurs preferentially across 10 base pairs, favored by delocalization over a full turn of the helix.

Indexed as

DNAModels, MolecularNucleic Acid ConformationOxidation-ReductionPhotochemistryDNA

Identifiers

PMID21348520
PMCPMC3079569
OpenAlexW2117550574

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.