ReviewReviews in endocrine & metabolic disorders2011
Hypothalamic AMP-activated protein kinase as a mediator of whole body energy balance.
Review in Reviews in endocrine & metabolic disorders, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 108 citations in OpenAlex.
- Dopamine D2 Receptors and Its Downstream Signaling in Compulsive Eating.Brain sciences · 2025Article
- Sex-based differences in growth-related IGF1 signaling in response to PAPP-A2 deficiency: comparative effects of rhGH, rhIGF1 and rhPAPP-A2 treatments.Biology of sex differences · 2024Article
- Protein Kinases in Obesity, and the Kinase-Targeted Therapy.Advances in experimental medicine and biology · 2024Review
- Modeling Structure-Activity Relationship of AMPK Activation.Molecules (Basel, Switzerland) · 2021Article
- Integration of Nutrient Sensing in Fish Hypothalamus.Frontiers in neuroscience · 2021Review
- Therapeutic Potential ofFrontiers in pharmacology · 2020Review
- Response of rainbow trout's (Oncorhynchus mykiss) hypothalamus to glucose and oleate assessed through transcription factors BSX, ChREBP, CREB, and FoxO1.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2018Article
- Nesfatin-1 Regulates Feeding, Glucosensing and Lipid Metabolism in Rainbow Trout.Frontiers in endocrinology · 2018Article
- Central Administration of 1-Deoxynojirimycin Attenuates Hypothalamic Endoplasmic Reticulum Stress and Regulates Food Intake and Body Weight in Mice with High-Fat Diet-Induced Obesity.Evidence-based complementary and alternative medicine : eCAM · 2017Article
- Hypothalamic AMPK: a canonical regulator of whole-body energy balance.Nature reviews. Endocrinology · 2016Review
- The hypotensive effect of acute and chronic AMP-activated protein kinase activation in normal and hyperlipidemic mice.Vascular pharmacology · 2015Article
- Electroacupuncture inhibits weight gain in diet-induced obese rats by activating hypothalamic LKB1-AMPK signaling.BMC complementary and alternative medicine · 2015Article
- The brain and brown fat.Annals of medicine · 2015Review
- Article
- Thiamine deficiency induces anorexia by inhibiting hypothalamic AMPK.Neuroscience · 2014Article
- AMPK: An emerging target for modification of injury-induced pain plasticity.Neuroscience letters · 2013Review
- The role of hypothalamic H1 receptor antagonism in antipsychotic-induced weight gain.CNS drugs · 2013Review
- Neuropsychological deficits in mice depleted of the schizophrenia susceptibility gene CSMD1.PloS one · 2013Article
- AMP-activated kinase links serotonergic signaling to glutamate release for regulation of feeding behavior in C. elegans.Cell metabolism · 2012Article
- AMP-Activated Protein Kinase (AMPK) and Energy-Sensing in the Brain.Experimental neurobiology · 2012Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 3 countries.
Funding
Abstract
The AMP-activated protein kinase (AMPK) is the downstream constituent of a kinase cascade that acts as a sensor of cellular energy levels. Current data unequivocally indicate that hypothalamic AMPK plays a key role in the control of the whole body energy balance, by integrating peripheral signals, such as hormones and metabolites, with central signals, such as neuropeptides, and eliciting allostatic changes in energy homeostasis. Although the molecular details of these interactions are not fully understood, recent evidence has suggested that the interaction between AMPK with hypothalamic lipid metabolism and other metabolic sensors, such as the uncoupling protein 2 (UCP-2), the mammalian target of rapamycin (mTOR) and the deacetylase sirtuin 1 (SIRT1), may play a main role in the hypothalamic control of feeding and energy expenditure. Here, we summarize the role of hypothalamic AMPK as whole body energy gauge. Understanding this key molecule and especially its functions at central level may provide new therapeutic targets for the treatment of metabolic alterations and obesity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.