ArticleJournal of the Association for Research in Otolaryngology : JARO2011
The medial olivocochlear system attenuates the developmental impact of early noise exposure.
Article in Journal of the Association for Research in Otolaryngology : JARO, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 51 citations in OpenAlex.
- Article
- Strengthening Medial Olivocochlear Feedback Reduces the Developmental Impact of Early Noise Exposure.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Strengthening Medial Olivocochlear Feedback Reduces the Developmental Impact of Early Noise Exposure.bioRxiv : the preprint server for biology · 2025Article
- Alpha9alpha10 knockout mice show altered physiological and behavioral responses to signals in masking noise.The Journal of the Acoustical Society of America · 2024Article
- Genetic tools for studying cochlear inhibition.Frontiers in cellular neuroscience · 2024Review
- Auditory brainstem mechanisms likely compensate for self-imposed peripheral inhibition.Scientific reports · 2023Article
- Engineering olivocochlear inhibition to reduce acoustic trauma.Molecular therapy. Methods & clinical development · 2023Article
- Sources of variability in auditory brainstem response thresholds in a mouse model of noise-induced hearing loss.The Journal of the Acoustical Society of America · 2022Article
- Auditory Behavior in Adult-Blinded Mice.Journal of the Association for Research in Otolaryngology : JARO · 2022Article
- Acoustic Trauma Increases Ribbon Number and Size in Outer Hair Cells of the Mouse Cochlea.Journal of the Association for Research in Otolaryngology : JARO · 2021Article
- Characterizing the Access of Cholinergic Antagonists to Efferent Synapses in the Inner Ear.Frontiers in neuroscience · 2021Article
- A Time-Course-Based Estimation of the Human Medial Olivocochlear Reflex Function Using Clicks.Frontiers in neuroscience · 2021Article
- Noise Exposure Potentiates Exocytosis From Cochlear Inner Hair Cells.Frontiers in synaptic neuroscience · 2021Article
- Differences in the Structure and Function of the Vestibular Efferent System Among Vertebrates.Frontiers in neuroscience · 2021Review
- Characterization of HA-tagged α9 and α10 nAChRs in the mouse cochlea.Scientific reports · 2020Article
- The role of efferents in human auditory development: efferent inhibition predicts frequency discrimination in noise for children.Journal of neurophysiology · 2020Article
- Article
- Effects of Non-traumatic Noise and Conductive Hearing Loss on Auditory System Function.Neuroscience · 2019Review
- Efferent Inhibition of the Cochlea.Cold Spring Harbor perspectives in medicine · 2019Review
- Talking back: Development of the olivocochlear efferent system.Wiley interdisciplinary reviews. Developmental biology · 2018Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
The early onset of peripheral deafness profoundly alters the functional maturation of the central auditory system. A prolonged exposure to an artificial acoustic environment has a similar disruptive influence. These observations establish the importance of normal patterns of sound-driven activity during the initial stages of auditory development. The present study was designed to address the role of cochlear gain control during these activity-dependent developmental processes. It was hypothesized that the regulation of auditory nerve activity by the medial olivocochlear system (MOCS) would preserve normal development when the immature auditory system was challenged by continuous background noise. To test this hypothesis, knock-out mice lacking MOCS feedback were reared in noisy or quiet environments and then evaluated with behavioral paradigms for auditory processing deficits. Relative to wild-type controls, noise-reared knock-out mice showed a decreased ability to process rapid acoustic events. Additional anatomical and physiological assessments linked these perceptual deficits to synaptic defects in the auditory brainstem that shared important features with human auditory neuropathy. Our findings offer a new perspective on the potentially damaging effects of environmental noise and how these risks are ameliorated by the protective role of MOCS feedback.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.