ArticleDie Naturwissenschaften2011
Cerumen of Australian stingless bees (Tetragonula carbonaria): gas chromatography-mass spectrometry fingerprints and potential anti-inflammatory properties.
Article in Die Naturwissenschaften, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 76 citations in OpenAlex.
- ComparativeMagnetic resonance in chemistry : MRC · 2026Article
- Article
- Propolis compound inhibits profibrotic TGF-β1/SMAD signalling in human fibroblasts.Scientific reports · 2025Article
- Bioactive Polyphenolic Compounds from Propolis ofFoods (Basel, Switzerland) · 2025Article
- Genome-Wide Association Studies Reveal That the Abietane Diterpene Isopimaric Acid Promotes Rice Growth through Inhibition of Defense Pathways.International journal of molecular sciences · 2024Article
- Differences in the biochemical content and radical scavenging activity of propolis from different parts of aRoyal Society open science · 2023Article
- Exploring the Functional Properties of Propolis, Geopropolis, and Cerumen, with a Special Emphasis on Their Antimicrobial Effects.Foods (Basel, Switzerland) · 2023Review
- Terpene-Containing Analogues of Glitazars as Potential Therapeutic Agents for Metabolic Syndrome.Current issues in molecular biology · 2023Article
- A review of stingless bees' bioactivity in different parts of the world.Journal of medicine and life · 2023Review
- Synergic Effect of Honey with Other Natural Agents in Developing Efficient Wound Dressings.Antioxidants (Basel, Switzerland) · 2022Review
- Anti-Fibrotic Potential of Tomentosenol A, a Constituent of Cerumen from the Australian Native Stingless Bee,Antioxidants (Basel, Switzerland) · 2022Article
- Effects of propolis supplementation on irritable bowel syndrome with constipation (IBS-C) and mixed (IBS-M) stool pattern: A randomized, double-blind clinical trial.Food science & nutrition · 2022Article
- Article
- Effect of Honey on Pediatric Radio/Chemotherapy-Induced Oral Mucositis (R/CIOM): A Systematic Review and Meta-Analysis.Evidence-based complementary and alternative medicine : eCAM · 2022Review
- Resin Use by Stingless Bees: A Review.Insects · 2021Review
- Antiviral, Antibacterial, Antifungal, and Antiparasitic Properties of Propolis: A Review.Foods (Basel, Switzerland) · 2021Review
- The Isorhamnetin-Containing Fraction of Philippine Honey Produced by the Stingless BeeMolecules (Basel, Switzerland) · 2021Article
- Stingless Bee Propolis: New Insights for Anticancer Drugs.Oxidative medicine and cellular longevity · 2021Review
- Phytochemicals, mineral contents, antioxidants, and antimicrobial activities of propolis produced by Brunei stingless beesSaudi journal of biological sciences · 2020Article
- Antioxidant-Based Medicinal Properties of Stingless Bee Products: Recent Progress and Future Directions.Biomolecules · 2020Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cerumen, or propolis, is a mixture of plant resins enriched with bee secretions. In Australia, stingless bees are important pollinators that use cerumen for nest construction and possibly for colony's health. While extensive research attests to the therapeutic properties of honeybee (Apis mellifera) propolis, the biological and medicinal properties of Australian stingless bee cerumen are largely unknown. In this study, the chemical and biological properties of polar extracts of cerumen from Tetragonula carbonaria in South East Queensland, Australia were investigated using gas chromatography-mass spectrometry (GC-MS) analyses and in vitro 5-lipoxygenase (5-LOX) cell-free assays. Extracts were tested against comparative (commercial tincture of A. mellifera propolis) and positive controls (Trolox and gallic acid). Distinct GC-MS fingerprints of a mixed diterpenic profile typical of native bee cerumen were obtained with pimaric acid (6.31 ± 0.97%, w/w), isopimaric acid (12.23 ± 3.03%, w/w), and gallic acid (5.79 ± 0.81%, w/w) tentatively identified as useful chemical markers. Characteristic flavonoids and prenylated phenolics found in honeybee propolis were absent. Cerumen extracts from T. carbonaria inhibited activity of 5-LOX, an enzyme known to catalyse production of proinflammatory mediators (IC₅₀ 19.97 ± 2.67 μg/ml, mean ± SEM, n = 4). Extracts had similar potency to Trolox (IC₅₀ 12.78 ± 1.82 μg/ml), but were less potent than honeybee propolis (IC₅₀ 5.90 ± 0.62 g/ml) or gallic acid (IC₅₀ 5.62 ± 0.35 μg/ml, P < 0.001). These findings warrant further investigation of the ecological and medicinal properties of this stingless bee cerumen, which may herald a commercial potential for the Australian beekeeping industry.
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