ArticleMolecules and cells2011
Regulation of mouse 4-1BB expression: multiple promoter usages and a splice variant.
Article in Molecules and cells, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
- Circulating CD137+ T Cells Correlate with Improved Response to Anti-PD1 Immunotherapy in Patients with Cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2022Article
- The Murine CD137/CD137 Ligand Signalosome: A Signal Platform Generating Signal Complexity.Frontiers in immunology · 2020Review
- CD137 expression in cancer cells: regulation and significance.Cancer communications (London, England) · 2019Article
- Review
- Regulation of CD137 expression through K-Ras signaling in pancreatic cancer cells.Cancer communications (London, England) · 2019Article
- Cross-talk between 4-1BB and TLR1-TLR2 Signaling in CD8+ T Cells Regulates TLR2's Costimulatory Effects.Cancer immunology research · 2016Article
- Cellular dissection of psoriasis for transcriptome analyses and the post-GWAS era.BMC medical genomics · 2014Article
- Identification of alternative transcripts encoding the essential murine gammaherpesvirus lytic transactivator RTA.Journal of virology · 2014Article
- Several cis-regulatory elements control mRNA stability, translation efficiency, and expression pattern of Prrxl1 (paired related homeobox protein-like 1).The Journal of biological chemistry · 2013Article
- Reverse signaling through the co-stimulatory ligand, CD137L, as a critical mediator of sterile inflammation.Molecules and cells · 2012Review
- 4-1BB signaling breaks the tolerance of maternal CD8+ T cells that are reactive with alloantigens.PloS one · 2012Article
- Hypoxia-induced soluble CD137 in malignant cells blocks CD137L-costimulation as an immune escape mechanism.OncoimmunologyArticle
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The expression of 4-1BB has been known to be dependent on T cell activation. Recent studies have, however, revealed that 4-1BB expression is not restricted to T cells. We sought to determine the molecular basis for the differential gene expression. Here we report the expression pattern of two mouse 4-1BB transcripts, type I and type II. Whereas the type I transcript was specifically expressed on immune organ as previously reported, the type II transcript was ubiquitously expressed in tissues and various cell lines. However, both type I and type II transcript were highly induced on activated T cells. Primer extension assay of the two 4-1BB transcripts suggested that mouse 4-1BB had more than two transcripts. Using luciferase assay we have identified three promoter regions (PI, PII and PIII), which located on upstream region of second exon 1, first exon 1, and exon 2, respectively. In particular, the type I transcript was preferentially induced when naïve T cells are stimulated by anti-CD3 monoclonal antibody (mAb) since NF-κB specifically binds to the putative NF-κB element of PI. We have also shown that a splice variant, in which the transmembrane domain was deleted, could inhibit 4-1BB signaling. The splicing variant was highly induced by TCR stimulation. Our results reveal 4-1BB also has a negative regulation system through soluble 4-1BB produced from a splice variant induced under activation conditions.
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