ArticleInternational journal of clinical oncology2011
Risk factors and clinical courses of chemoradiation-related arterio-esophageal fistula in esophageal cancer patients with clinical invasion of the aorta.
Article in International journal of clinical oncology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Efficacy of thoracic endovascular aortic repair for aorto-esophageal fistula due to esophageal cancer: a systematic review and meta-analysis.Esophagus : official journal of the Japan Esophageal Society · 2024Pooled it
- Trial
- Thoracic endovascular aortic repair for advanced esophageal cancer invading the aorta: A prognosis analysis among 124 patients.JTCVS open · 2025Article
- Endoscopic balloon tamponade for massive bleeding from aorto-esophageal fistula: a simple technique for rapid hemostasis.Endoscopy · 2025Article
- Preprocedural computed tomography angiography-guided transcatheter arterial embolization for managing esophageal cancer bleeding: a case series study.Frontiers in oncology · 2025Article
- Aortoesophageal fistula 19 years after radiotherapy for oesophageal cancer: a case report.European heart journal. Case reports · 2024Article
- Aortoesophageal fistula due to esophageal cancer: a case report of successful management.Surgical case reports · 2024Article
- Risk factors for aortoesophageal fistula in cT4b esophageal squamous cell carcinoma after definitive radiation therapy.Journal of thoracic disease · 2023Article
- Tracheoesophageal fistula closure after staged dose-escalated radiotherapy for esophageal squamous cell carcinoma: a case report.The Journal of international medical research · 2023Article
- Article
- Treatment mode and prognosis of esophageal perforation after radiotherapy in patients with esophageal carcinoma.Frontiers in oncology · 2022Article
- Incorporation of PET Metabolic Parameters With Clinical Features Into a Predictive Model for Radiotherapy-Related Esophageal Fistula in Esophageal Squamous Cell Carcinoma.Frontiers in oncology · 2022Article
- Article
- Acute upper gastrointestinal bleeding caused by esophageal right bronchial artery fistula: A case report.World journal of gastrointestinal endoscopy · 2021Article
- Midthoracic Pain, Sentinel Arterial Haemorrhage and Exsanguination after a Symptom-Free Interval (Chiari's Triad) is Diagnostic of Arterio-Oesophageal Fistula: A Life-Threatening Cause of Gastrointestinal Bleeding.European journal of case reports in internal medicine · 2021Article
- Massive upper gastrointestinal bleeding caused by an intercostal arterio-esophageal fistula: A rare case report.Radiology case reports · 2020Article
- Survival and prognostic factors of patients with esophageal fistula in advanced esophageal squamous cell carcinoma.Bioscience reports · 2020Article
- Analysis of fistula formation of T4 esophageal cancer patients treated by chemoradiotherapy.Esophagus : official journal of the Japan Esophageal Society · 2020Article
- Risk Factors Associated with Esophageal Fistula after Radiotherapy for Esophageal Squamous Cell Carcinoma.Journal of Cancer · 2020Article
- Development and validation of a risk prediction model for radiotherapy-related esophageal fistula in esophageal cancer.Radiation oncology (London, England) · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough concurrent chemoradiotherapy (CRT) is a standard treatment for esophageal cancer invading adjacent structures (T4-EC), arterio-esophageal fistula (AEF) occurs occasionally as a critical adverse event of T4-EC with CRT. The frequency, clinical course, and risk factors of AEF related to CRT are not well known.
methodsWe retrospectively analyzed 48 patients with T4-EC invasion of the aorta who were treated with 5-fluorouracil, cisplatin, and concurrent radiotherapy at our institution between September 2002 and April 2009. Treatment-related AEF was defined as AEF without obvious tumor progression. We evaluated the frequency, clinical courses, and risk factors of AEF.
resultsThe median survival time was 10.6 months with a median follow-up time of 33.3 months. The 2-year survival rate was 25%. Treatment-related AEF was observed in 7 patients (14.6%) and 4 of them died of massive bleeding due to aortic AEF. In the other 3 patients with non-aortic AEF, hemorrhage could be arrested by transcatheter arterial embolization (TAE). In the univariate analysis of risk factors for AEF, lower serum cholesterol level was a risk factor for AEF (OR 14.7; 95% CI 1.58-137; P = 0.008).
conclusionsAlthough CRT has a curative potential even for patients with T4-EC invading the aorta, we should be aware of the relatively high incidence of treatment-related AEF. TAE may be successful in rescuing a non-aortic AEF patient. Low serum cholesterol level may be a risk factor for AEF, but further investigation is needed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.