ArticleThe Journal of membrane biology2011
Evolution of the oligopeptide transporter family.
Article in The Journal of membrane biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 58 citations in OpenAlex.
- Genome-wide identification of the oligopeptide transporter gene family in poplar and their responses to iron and cadmium.BMC plant biology · 2025Article
- Genome-Wide Identification of the OPT Gene Family and Screening of Sb-Responsive Genes inPlants (Basel, Switzerland) · 2025Article
- Proteomic and metabolomic profiling of extracellular vesicles produced by human gut archaea.Nature communications · 2025Article
- Comprehensive Genomic Analysis ofGenes · 2025Article
- Ubiquitous genome streamlinedISME communications · 2024Article
- Cryo-Treatment Enhances the Embryogenicity of Mature Somatic Embryos via the lncRNA-miRNA-mRNA Network in White Spruce.International journal of molecular sciences · 2022Article
- RNA-Seq-based high-resolution linkage map reveals the genetic architecture of fruiting body development in shiitake mushroom,Computational and structural biotechnology journal · 2021Article
- Diversity of Oligopeptide Transport in Yeast and Its Impact on Adaptation to Winemaking Conditions.Frontiers in genetics · 2020Review
- Molecular Basis of Unexpected Specificity of ABC Transporter-Associated Substrate-Binding Protein DppA from Helicobacter pylori.Journal of bacteriology · 2019Article
- Transcriptional regulator ArcA mediates expression of oligopeptide transport systems both directly and indirectly in Shewanella oneidensis.Scientific reports · 2019Article
- Comparative proteome analysis in an Escherichia coli CyDisCo strain identifies stress responses related to protein production, oxidative stress and accumulation of misfolded protein.Microbial cell factories · 2019Article
- Genome-Wide Identification and Comparative Analysis for OPT Family Genes inMolecules (Basel, Switzerland) · 2018Article
- Genome-wide analysis indicates diverse physiological roles of the turnip (Plant diversity · 2018Article
- Moving the Cellular Peptidome by Transporters.Frontiers in cell and developmental biology · 2018Review
- Recent advances in understanding proton coupled peptide transport via the POT family.Current opinion in structural biology · 2017Review
- Intracellular Action of a Secreted Peptide Required for Fungal Virulence.Cell host & microbe · 2016Article
- The Transporter Classification Database (TCDB): recent advances.Nucleic acids research · 2016Article
- Properties and Phylogeny of 76 Families of Bacterial and Eukaryotic Organellar Outer Membrane Pore-Forming Proteins.PloS one · 2016Article
- Charged/Polar-residue scanning of the hydrophobic face of transmembrane domain 9 of the yeast glutathione transporter, hgt1p, reveals a conformationally critical region for substrate transport.G3 (Bethesda, Md.) · 2015Article
- Molecular insights into proton coupled peptide transport in the PTR family of oligopeptide transporters.Biochimica et biophysica acta · 2015Review
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The oligopeptide transporter (OPT) family of peptide and iron-siderophore transporters includes members from both prokaryotes and eukaryotes but with restricted distribution in the latter domain. Eukaryotic members were found only in fungi and plants with a single slime mold homologue clustering with the fungal proteins. All functionally characterized eukaryotic peptide transporters segregate from the known iron-siderophore transporters on a phylogenetic tree. Prokaryotic members are widespread, deriving from many different phyla. Although they belong only to the iron-siderophore subdivision, genome context analyses suggest that many of them are peptide transporters. OPT family proteins have 16 or occasionally 17 transmembrane-spanning α-helical segments (TMSs). We provide statistical evidence that the 16-TMS topology arose via three sequential duplication events followed by a gene-fusion event for proteins with a seventeenth TMS. The proposed pathway is as follows: 2 TMSs → 4 TMSs → 8 TMSs → 16 TMSs → 17 TMSs. The seventeenth C-terminal TMS, which probably arose just once, is found in just one phylogenetic group of these homologues. Analyses for orthology revealed that a few phylogenetic clusters consist exclusively of orthologues but most have undergone intermixing, suggestive of horizontal transfer. It appears that in this family horizontal gene transfer was frequent among prokaryotes, rare among eukaryotes and largely absent between prokaryotes and eukaryotes as well as between plants and fungi. These observations provide guides for future structural and functional analyses of OPT family members.
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