ArticleDigestive diseases and sciences2011
Comparison of endoscopic and clinical characteristics of patients with familial and sporadic Barrett's esophagus.
Article in Digestive diseases and sciences, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.
- Systematic review with meta-analysis: the effects of family history on the risk of Barrett's oesophagus and oesophageal adenocarcinoma.Alimentary pharmacology & therapeutics · 2021Pooled it
- Esophageal adenocarcinoma in a first-degree relative increases risk for esophageal adenocarcinoma in patients with Barrett's esophagus.United European gastroenterology journal · 2019Article
- Germline variant in MSX1 identified in a Dutch family with clustering of Barrett's esophagus and esophageal adenocarcinoma.Familial cancer · 2018Article
- The Genetics of Barrett's Esophagus: A Familial and Population-Based Perspective.Digestive diseases and sciences · 2016Review
- Early onset esophageal adenocarcinoma: a distinct molecular entity?Oncoscience · 2016Article
- Hereditary Factors in Esophageal Adenocarcinoma.Gastrointestinal tumors · 2014Review
- Managing Barrett's esophagus with radiofrequency ablation.Gastroenterology report · 2013Article
- Familial Barrett's esophagus: clues to genetic risks for esophageal adenocarcinoma.Digestive diseases and sciences · 2011Article
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6 authors at 4 institutions in 1 country.
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Abstract
backgroundA proportion of Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC) displays familial aggregation, known as familial Barrett's esophagus (FBE). Pedigrees and characteristics of EAC in these families have been previously described.
aimsWe aimed to evaluate endoscopic and clinical characteristics of Barrett's esophagus in FBE.
methodsA cohort of 979 BE patients were retrospectively evaluated for FBE, defined as having a first-degree relative with BE or esophageal cancer, confirmed when possible by interview. FBE and sporadic BE were compared regarding demographic, clinical, and endoscopic characteristics. Potential FBE probands were contacted and interviewed to obtain full family pedigrees.
resultsOf 603 BE probands (61.6% of total cohort) with a documented family history, 35 (5.8%) had FBE. There was no difference between FBE and non-FBE probands with regard to BE length (median: 3 cm, IQR 2-5 vs. 3 cm, IQR 1-6 cm, respectively; p = 0.78) or hiatal hernia size (p = 0.90). FBE probands were younger (mean, 58.4 vs. 63.8; p = 0.02) and had a significant association with less-advanced neoplasia (adjusted OR 0.41, 95% CI 0.19-0.90). There was no obvious association between FBE and other malignancies.
conclusionsThere were no differences in endoscopic characteristics between FBE and non-FBE probands. While FBE patients were younger and had less-advanced neoplasia, we speculate that these findings may have been the result of more aggressive screening due to the family history. Further studies are warranted to determine whether familial clustering is due to genetic predisposition to development of BE or to risk of neoplastic progression.
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