ArticlePLoS neglected tropical diseases2011
A coproantigen diagnostic test for Strongyloides infection.
Article in PLoS neglected tropical diseases, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 78 citations in OpenAlex.
- Prevalence of strongyloidiasis in the general population of the world: a systematic review and meta-analysis.Pathogens and global health · 2021Pooled it
- The laboratory diagnosis and follow up of strongyloidiasis: a systematic review.PLoS neglected tropical diseases · 2013Pooled it
- Neglected tropical disease (NTD) diagnostics: current development and operations to advance control.Pathogens and global health · 2024Review
- Strongyloidiasis.Nature reviews. Disease primers · 2024Review
- Astacin metalloproteases in human-parasitic nematodes.Advances in parasitology · 2024Review
- Human strongyloidiasis: complexities and pathways forward.Clinical microbiology reviews · 2023Review
- A comparative 'omics' approach for prediction of candidate Strongyloides stercoralis diagnostic coproantigens.PLoS neglected tropical diseases · 2023Article
- Improved diagnostic sensitivity of human strongyloidiasis using point-of-care mixed recombinant antigen-based immunochromatography.Parasite (Paris, France) · 2023Article
- Direct detection of Strongyloides infection via molecular and antigen detection methods.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2021Review
- Diagnostic Techniques for Soil-Transmitted Helminths - Recent Advances.Research and reports in tropical medicine · 2021Review
- Effectiveness ofDiagnostics (Basel, Switzerland) · 2020Article
- Diagnostic Techniques of Soil-Transmitted Helminths: Impact on Control Measures.Tropical medicine and infectious disease · 2020Review
- Development of immunochromatographic device as a point-of-care tool for serodiagnosis of human strongyloidiasis cases.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2020Article
- Article
- Clinical and Diagnostic Features of 413 Patients Treated for Imported Strongyloidiasis at the Hospital for Tropical Diseases, London.The American journal of tropical medicine and hygiene · 2019Article
- Transrenal DNA-based diagnosis of Strongyloides stercoralis (Grassi, 1879) infection: Bayesian latent class modeling of test accuracy.PLoS neglected tropical diseases · 2018Article
- Human infection with Strongyloides stercoralis and other related Strongyloides species.Parasitology · 2017Review
- Review
- Adult female of Strongyloides stercoralis in respiratory secretions.Asian Pacific journal of tropical biomedicine · 2013Article
- Diagnosis, treatment and risk factors of Strongyloides stercoralis in schoolchildren in Cambodia.PLoS neglected tropical diseases · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Accurate diagnosis of infection with the parasite Strongyloides stercoralis is hampered by the low concentration of larvae in stool, rendering parasitological diagnosis insensitive. Even if the more sensitive agar plate culture method is used repeated stool sampling is necessary to achieve satisfactory sensitivity. In this manuscript we describe the development of a coproantigen ELISA for diagnosis of infection. Polyclonal rabbit antiserum was raised against Strongyloides ratti excretory/secretory (E/S) antigen and utilized to develop an antigen capture ELISA. The assay enabled detection of subpatent rodent S. ratti and human S. stercoralis infection. No cross-reactivity was observed with purified E/S from Schistosoma japonicum, the hookworms Ancylostoma caninum, A. ceylanicum, nor with fecal samples collected from rodents harboring Trichuris muris or S. mansoni infection. Strongyloides coproantigens that appear stable when frozen as formalin-extracted fecal supernatants stored at -20 °C remained positive up to 270 days of storage, whereas supernatants stored at 4 °C tested negative. These results indicate that diagnosis of human strongyloidiasis by detection of coproantigen is an approach worthy of further development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.