ArticlePloS one2011
Analysis of male pheromones that accelerate female reproductive organ development.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 58 citations in OpenAlex.
- Effect of the duration of visual exposure to the male on the reproductive performance of nulliparous guinea pigs.Brazilian journal of veterinary medicine · 2026Article
- Male-mediated early maturation unlikely to evolve via adaptive evolution.Animal behaviour · 2024Article
- Female scent accelerates growth of juvenile male mice.Scientific reports · 2023Article
- Notch signaling determines cell-fate specification of the two main types of vomeronasal neurons of rodents.Development (Cambridge, England) · 2022Article
- Regulation of Sexually Dimorphic Expression of Major Urinary Proteins.Frontiers in physiology · 2022Review
- Pheromones that correlate with reproductive success in competitive conditions.Scientific reports · 2021Article
- Mechanisms underlying pre- and postnatal development of the vomeronasal organ.Cellular and molecular life sciences : CMLS · 2021Review
- Sensory Detection by the Vomeronasal Organ Modulates Experience-Dependent Social Behaviors in Female Mice.Frontiers in cellular neuroscience · 2021Article
- A new defense in the battle of the sexes.eLife · 2019Article
- Article
- Regulation of volatile and non-volatile pheromone attractants depends upon male social status.Scientific reports · 2019Article
- Identification and Field Testing of Volatile Components in the Sex Attractant Pheromone Blend of Female House Mice.Journal of chemical ecology · 2019Article
- Signal Detection and Coding in the Accessory Olfactory System.Chemical senses · 2018Review
- Metabolic Biomarkers of Ageing in C57BL/6J Wild-Type and Flavin-Containing Monooxygenase 5 (FMO5)-Knockout Mice.Frontiers in molecular biosciences · 2018Article
- Activity Dependent Modulation of Granule Cell Survival in the Accessory Olfactory Bulb at Puberty.Frontiers in neuroanatomy · 2017Article
- TRPC Channels and Parkinson's Disease.Advances in experimental medicine and biology · 2017Review
- Evidence for early intracellular accumulation of volatile compounds during spadix development in Arum italicum L. and preliminary data on some tropical Aroids.Die Naturwissenschaften · 2014Article
- Article
- A wide range of pheromone-stimulated sexual and reproductive behaviors in female mice depend on G protein Gαo.BMC biology · 2014Article
- Mammalian pheromones.Annual review of physiology · 2014Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Male odors can influence a female's reproductive physiology. In the mouse, the odor of male urine results in an early onset of female puberty. Several volatile and protein pheromones have previously been reported to each account for this bioactivity. Here we bioassay inbred BALB/cJ females to study pheromone-accelerated uterine growth, a developmental hallmark of puberty. We evaluate the response of wild-type and mutant mice lacking a specialized sensory transduction channel, TrpC2, and find TrpC2 function to be necessary for pheromone-mediated uterine growth. We analyze the relative effectiveness of pheromones previously identified to accelerate puberty through direct bioassay and find none to significantly accelerate uterine growth in BALB/cJ females. Complementary to this analysis, we have devised a strategy of partial purification of the uterine growth bioactivity from male urine and applied it to purify bioactivity from three different laboratory strains. The biochemical characteristics of the active fraction of all three strains are inconsistent with that of previously known pheromones. When directly analyzed, we are unable to detect previously known pheromones in urine fractions that generate uterine growth. Our analysis indicates that pheromones emitted by males to advance female puberty remain to be identified.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.