ArticlePloS one2011
Persistence of livestock associated MRSA CC398 in humans is dependent on intensity of animal contact.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 99 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
99 citing papers in PubMed, 1 synthesis or guideline pooled it, 215 citations in OpenAlex.
- The effectiveness of biosecurity interventions in reducing the transmission of bacteria from livestock to humans at the farm level: A systematic literature review.Zoonoses and public health · 2021Pooled it
- Bovine MastitisAntibiotics (Basel, Switzerland) · 2026Article
- Characterization ofAntibiotics (Basel, Switzerland) · 2025Article
- Cross-Sectional Study on Zoonotic Bacteria Carriage by Small Ruminants from Portugal's Central Region.Pathogens (Basel, Switzerland) · 2025Article
- Multiple antimicrobial resistance indices of Staphylococcus aureus from the nares of goats and slaughterhouse attendants in Kampala city, Uganda- a cross sectional study.BMC microbiology · 2025Article
- Genetic characteristics and antimicrobial resistance of Staphylococcus aureus isolates from pig farms in Korea: emergence of cfr-positive CC398 lineage.BMC veterinary research · 2024Article
- Molecular Evolution and Pathogenicity of Methicillin-ResistantAntibiotics (Basel, Switzerland) · 2024Article
- Methicillin-resistantVeterinary world · 2024Review
- Time-calibrated phylogenetic and chromosomal mobilome analyses of Staphylococcus aureus CC398 reveal geographical and host-related evolution.Nature communications · 2024Article
- Virulence attributes of successful methicillin-resistantClinical microbiology reviews · 2023Review
- Virulence Mechanisms of Staphylococcal Animal Pathogens.International journal of molecular sciences · 2023Review
- Computational Screening of Approved Drugs for Inhibition of the Antibiotic Resistance GeneBiotech (Basel (Switzerland)) · 2023Article
- Identification and Validation of a Novel Antibacterial Compound MZ-01 against Methicillin-ResistantAntibiotics (Basel, Switzerland) · 2022Article
- Antimicrobial Resistance and Molecular Characterization of Methicillin-ResistantAntibiotics (Basel, Switzerland) · 2022Article
- One Health: a holistic approach for food safety in livestock.Science in One Health · 2022Review
- Nickel Nanoparticles: Applications and Antimicrobial Role against Methicillin-ResistantAntibiotics (Basel, Switzerland) · 2022Review
- TheGenes · 2021Review
- Livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) prevalence in humans in close contact with animals and measures to reduce on-farm colonisation.Irish veterinary journal · 2021Review
- Exudative Epidermitis in Combination with Staphylococcal Pyoderma in Suckling Piglets.Antibiotics (Basel, Switzerland) · 2021Article
- Occurrence and Survival of Livestock-Associated MRSA in Pig Manure and on Agriculture Fields.Antibiotics (Basel, Switzerland) · 2021Article
39 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe presence of Livestock Associated MRSA (LA-MRSA) in humans is associated with intensity of animal contact. It is unknown whether the presence of LA-MRSA is a result of carriage or retention of MRSA-contaminated dust. We conducted a longitudinal study among 155 veal farmers in which repeated nasal and throat swabs were taken for MRSA detection. Periods with and without animal exposure were covered.
methodsRandomly, 51 veal calf farms were visited from June-December 2008. Participants were asked to fill in questionnaires (n = 155) to identify potential risk factors for MRSA colonisation. Nasal and throat swabs were repeatedly taken from each participant for approximately 2 months. Swabs were analysed for MRSA and MSSA by selective bacteriological culturing. Spa-types of the isolates were identified and a ST398 specific PCR was performed. Data were analyzed using generalized estimation equations (GEE) to allow for correlated observations within individuals.
resultsMean MRSA prevalence was 38% in farmers and 16% in family members. Presence of MRSA in farmers was strongly related to duration of animal contact and was strongly reduced in periods with absence of animal contact (-58%). Family members, especially children, were more often carriers when the farmer was a carrier (OR = 2, P<0.05). Only 7% (n = 11) of the participants appeared to be persistent carriers. A large heterogeneity in spa-types was detected, however 92.7% belonged to LA-MRSA CC398. A surprisingly high fraction of the spa-types (7.3%) did not belong to CC398.
conclusionThe presence of LA-MRSA in farmers is strongly animal-exposure related. The rapidly decreasing MRSA prevalence during absence of animal contact suggests that LA-MRSA is a poor persistent colonizer in most humans. These results are of relevance for MRSA control strategies.
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Registered trials
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