ArticlePLoS computational biology2011
A computational clonal analysis of the developing mouse limb bud.
Article in PLoS computational biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 41 citations in OpenAlex.
- Development of whole-limb skeletal patterning through the coordination of growth and self-organization models.PLoS computational biology · 2026Article
- LimbNET: collaborative platform for simulating spatial patterns of gene networks in limb development.Molecular systems biology · 2026Article
- Morphogen gradients are regulated by porous media characteristics of the developing tissue.Development (Cambridge, England) · 2025Article
- Spatio-temporal reconstruction of gene expression patterns in developing mice.Development (Cambridge, England) · 2025Article
- Compressive stress gradients direct mechanoregulation of anisotropic growth in the zebrafish jaw joint.PLoS computational biology · 2024Article
- Comparative profiling of cellular gait on adhesive micropatterns defines statistical patterns of activity that underlie native and cancerous cell dynamics.bioRxiv : the preprint server for biology · 2023Article
- Cell cycle dynamics control fluidity of the developing mouse neuroepithelium.Nature physics · 2023Article
- Growth orientations, rather than heterogeneous growth rates, dominate jaw joint morphogenesis in the larval zebrafish.Journal of anatomy · 2022Article
- Mechanical Regulation of Limb Bud Formation.Cells · 2022Review
- Expression analysis of limb element markers during mouse embryonic development.Developmental dynamics : an official publication of the American Association of Anatomists · 2018Article
- The two domain hypothesis of limb prepattern and its relevance to congenital limb anomalies.Wiley interdisciplinary reviews. Developmental biology · 2017Review
- The fin-to-limb transition as the re-organization of a Turing pattern.Nature communications · 2016Article
- Geometric Morphometrics on Gene Expression Patterns Within Phenotypes: A Case Example on Limb Development.Systematic biology · 2016Article
- Data-driven modelling of a gene regulatory network for cell fate decisions in the growing limb bud.Molecular systems biology · 2015Article
- Quantitative analysis of tissue deformation dynamics reveals three characteristic growth modes and globally aligned anisotropic tissue deformation during chick limb development.Development (Cambridge, England) · 2015Article
- Limb, tooth, beak: three modes of development and evolutionary innovation of form.Journal of biosciences · 2014Article
- Whole population cell analysis of a landmark-rich mammalian epithelium reveals multiple elongation mechanisms.Development (Cambridge, England) · 2013Article
- Simulating cortical development as a self constructing process: a novel multi-scale approach combining molecular and physical aspects.PLoS computational biology · 2013Article
- Development: Budding potential.Nature reviews. Genetics · 2011Article
- A landmark-free morphometric staging system for the mouse limb bud.Development (Cambridge, England) · 2011Article
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Authors and funding
4 authors at 3 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
A comprehensive spatio-temporal description of the tissue movements underlying organogenesis would be an extremely useful resource to developmental biology. Clonal analysis and fate mappings are popular experiments to study tissue movement during morphogenesis. Such experiments allow cell populations to be labeled at an early stage of development and to follow their spatial evolution over time. However, disentangling the cumulative effects of the multiple events responsible for the expansion of the labeled cell population is not always straightforward. To overcome this problem, we develop a novel computational method that combines accurate quantification of 2D limb bud morphologies and growth modeling to analyze mouse clonal data of early limb development. Firstly, we explore various tissue movements that match experimental limb bud shape changes. Secondly, by comparing computational clones with newly generated mouse clonal data we are able to choose and characterize the tissue movement map that better matches experimental data. Our computational analysis produces for the first time a two dimensional model of limb growth based on experimental data that can be used to better characterize limb tissue movement in space and time. The model shows that the distribution and shapes of clones can be described as a combination of anisotropic growth with isotropic cell mixing, without the need for lineage compartmentalization along the AP and PD axis. Lastly, we show that this comprehensive description can be used to reassess spatio-temporal gene regulations taking tissue movement into account and to investigate PD patterning hypothesis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.