Evidence map›Paper›PMID 21346964›Full record

ArticleAMIA ... Annual Symposium proceedings. AMIA Symposium2010

ADESSA: A Real-Time Decision Support Service for Delivery of Semantically Coded Adverse Drug Event Data.

Jon D Duke, Jeff Friedlin

Abstract read
In one paragraph

Article in AMIA ... Annual Symposium proceedings. AMIA Symposium, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  4. Article
  5. Review
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  7. Article
  8. Article
  9. Article
  10. Scaling drug indication curation through crowdsourcing.Database : the journal of biological databases and curation · 2015
    Article
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  12. Article
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  16. Semantic processing to identify adverse drug event information from black box warnings.AMIA ... Annual Symposium proceedings. AMIA Symposium · 2014
    Article
  17. Article
  18. Extracting drug indication information from structured product labels using natural language processing.Journal of the American Medical Informatics Association : JAMIA · 2013
    Article
  19. Mining FDA drug labels for medical conditions.BMC medical informatics and decision making · 2013
    Article
  20. Semantic processing to identify adverse drug event information from black box warnings.AMIA ... Annual Symposium proceedings. AMIA Symposium · 2013
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Jon D DukeRegenstrief Institute, Indianapolis, IN;
Jeff Friedlin

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Evaluating medications for potential adverse events is a time-consuming process, typically involving manual lookup of information by physicians. This process can be expedited by CDS systems that support dynamic retrieval and filtering of adverse drug events (ADE's), but such systems require a source of semantically-coded ADE data. We created a two-component system that addresses this need. First we created a natural language processing application which extracts adverse events from Structured Product Labels and generates a standardized ADE knowledge base. We then built a decision support service that consumes a Continuity of Care Document and returns a list of patient-specific ADE's. Our database currently contains 534,125 ADE's from 5602 product labels. An NLP evaluation of 9529 ADE's showed recall of 93% and precision of 95%. On a trial set of 30 CCD's, the system provided adverse event data for 88% of drugs and returned these results in an average of 620ms.

Indexed as

Drug-Related Side Effects and Adverse ReactionsNatural Language ProcessingAdverse Drug Reaction Reporting SystemsDatabases, FactualHumansKnowledge BasesSemantics

Identifiers

PMID21346964
PMCPMC3041415

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.