ArticleBioinformation2010
A novel strategy of epitope design in Neisseria gonorrhoeae.
Article in Bioinformation, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 51 citations in OpenAlex.
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- An Integrated Approach to Develop a Potent Vaccine Candidate Construct Against Prostate Cancer by Utilizing Machine Learning and Bioinformatics.Cancer reports (Hoboken, N.J.) · 2024Article
- Immunoinformatic-guided designing of multi-epitope vaccine construct against Brucella Suis 1300.Immunologic research · 2023Article
- Immunoinformatics Vaccine Design for Zika Virus.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Identification of vaccine and drug targets in Shigella dysenteriae sd197 using reverse vaccinology approach.Scientific reports · 2022Article
- Immunoinformatic design of a putative multi-epitope vaccine candidate againstComputational and structural biotechnology journal · 2022Article
- Identification and Design of a Next-Generation Multi Epitopes Bases Peptide Vaccine Candidate Against Prostate Cancer: An In Silico Approach.Cell biochemistry and biophysics · 2020Article
- Contriving Multi-Epitope Subunit of Vaccine for COVID-19: Immunoinformatics Approaches.Frontiers in immunology · 2020Article
- Epitope-Based Vaccine Designing ofInternational journal of peptide research and therapeutics · 2020Article
- A systematic strategy for the investigation of vaccines and drugs targeting bacteria.Computational and structural biotechnology journal · 2020Review
- Subtractive proteomics to identify novel drug targets and reverse vaccinology for the development of chimeric vaccine against Acinetobacter baumannii.Scientific reports · 2018Article
- In silico prediction of cancer immunogens: current state of the art.BMC immunology · 2018Review
- In silico prediction of monovalent and chimeric tetravalent vaccines for prevention and treatment of dengue fever.Journal of biomedical research · 2017Article
- Exploring dengue genome to construct a multi-epitope based subunit vaccine by utilizing immunoinformatics approach to battle against dengue infection.Scientific reports · 2017Article
- In silico structure analysis and epitope prediction of E3 CR1-beta protein of Human Adenovirus E for vaccine design.Biomedical journal · 2016Article
- Implications from predicted B-cell and T-cell epitopes of Plasmodium falciparum merozoite proteins EBA175-RII and Rh5.Bioinformation · 2016Article
- Emerging Vaccine Technologies.Vaccines · 2015Review
- Genome informatics and vaccine targets in Corynebacterium urealyticum using two whole genomes, comparative genomics, and reverse vaccinology.BMC genomics · 2015Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In spite of genome sequences of both human and N. gonorrhoeae in hand, vaccine for gonorrhea is yet not available. Due to availability of several host and pathogen genomes and numerous tools for in silico prediction of effective B-cell and T-cell epitopes; recent trend of vaccine designing has been shifted to peptide or epitope based vaccines that are more specific, safe, and easy to produce. In order to design and develop such a peptide vaccine against the pathogen, we adopted a novel computational approache based on sequence, structure, QSAR, and simulation methods along with fold level analysis to predict potential antigenic B-cell epitope derived T-cell epitopes from four vaccine targets of N. gonorrhoeae previously identified by us [Barh and Kumar (2009) In Silico Biology 9, 1-7]. Four epitopes, one from each protein, have been designed in such a way that each epitope is highly likely to bind maximum number of HLA molecules (comprising of both the MHC-I and II) and interacts with most frequent HLA alleles (A*0201, A*0204, B*2705, DRB1*0101, and DRB1*0401) in human population. Therefore our selected epitopes are highly potential to induce both the B-cell and T-cell mediated immune responses. Of course, these selected epitopes require further experimental validation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.