ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2011
Impact of common KIBRA allele on human cognitive functions.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed.
- Article
- Review
- Is the Brain an Early or Late Component of Essential Hypertension?American journal of hypertension · 2020Review
- KIBRA T allele influences memory performance and progression of cognitive decline: a 7-year follow-up study in subjective cognitive decline and mild cognitive impairment.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2019Article
- The role of KIBRA in reconstructive episodic memory.Molecular medicine (Cambridge, Mass.) · 2018Article
- KIBRA is associated with accelerated cognitive decline and hippocampal atrophy in APOE ε4-positive cognitively normal adults with high Aβ-amyloid burden.Scientific reports · 2018Article
- No differences in brain microstructure between young KIBRA-C carriers and non-carriers.Oncotarget · 2018Article
- Aging and a genetic KIBRA polymorphism interactively affect feedback- and observation-based probabilistic classification learning.Neurobiology of aging · 2018Article
- Hippo Signaling: Emerging Pathway in Stress-Related Psychiatric Disorders?Frontiers in psychiatry · 2018Review
- Age is no barrier: predictors of academic success in older learners.NPJ science of learning · 2017Article
- Age-Modulated Associations betweenFrontiers in aging neuroscience · 2017Article
- Impact of Hypertension on Cognitive Function: A Scientific Statement From the American Heart Association.Hypertension (Dallas, Tex. : 1979) · 2016Review
- Impact of KIBRA Polymorphism on Memory Function and the Hippocampus in Older Adults.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Article
- Serum KIBRA mRNA and Protein Expression and Cognitive Functions in Depression.Medical science monitor : international medical journal of experimental and clinical research · 2016Article
- KIBRA: In the brain and beyond.Cellular signalling · 2014Article
- WWC1 genotype modulates age-related decline in episodic memory function across the adult life span.Biological psychiatry · 2014Article
- Tissue-specific differences in the regulation of KIBRA gene expression involve transcription factor TCF7L2 and a complex alternative promoter system.Journal of molecular medicine (Berlin, Germany) · 2014Article
- KIBRA gene polymorphism has no association with verbal or visual episodic memory performance.Frontiers in aging neuroscience · 2014Article
- KIBRA polymorphism is associated with individual differences in hippocampal subregions: evidence from anatomical segmentation using high-resolution MRI.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Common exonic missense variants in the C2 domain of the human KIBRA protein modify lipid binding and cognitive performance.Translational psychiatry · 2013Article
Corrections and comments
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The rs17070145 polymorphism (C → T substitution, intron 9) of the KIBRA gene has recently been associated with episodic memory and cognitive flexibility. These findings were inconsistent across reports though, and largely lacked gene-gene or gene-environment interactions. The aim of the present study was to determine the impact of the rs17070145 polymorphism on clinically relevant cognitive domains and its interaction with the modifiers 'lifestyle' and 'cardiovascular risk factors'. Five-hundred forty-five elderly volunteers (mean age 64 years, ±7 years, 56% women) accomplished a comprehensive cognitive testing. Principal component analysis was used to reveal the internal structure of the data, rendering four composite scores: verbal memory, word fluency, executive function/psychomotor speed, and working memory. Lifestyle was assessed with a detailed questionnaire, age-associated risk factors by clinical interview and examination. There was no main effect of the rs17070145 genotype on any cognitive composite scores. However, we found worse performance in executive functions for T-allele carriers in the presence of arterial hypertension (β=-0.365, p=0.0077 and 0.031 after Bonferroni correction). This association was further modified by gender, showing the strongest association in hypertensive females (β=-0.500, p=0.0072 and 0.029 after Bonferroni correction). The effect of KIBRA on cognitive function seems to be complex and modified by gender and arterial hypertension.
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