ArticleCell cycle (Georgetown, Tex.)2011
A precursor microRNA in a cancer cell nucleus: get me out of here!
Article in Cell cycle (Georgetown, Tex.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 46 citations in OpenAlex.
- Prognostic significance of exportin-5 in hepatocellular carcinoma.World journal of gastrointestinal oncology · 2024Article
- Unleash Multifunctional Role of miRNA Biogenesis Gene Variants (Journal of personalized medicine · 2023Article
- Identification of crucial genes involved in thyroid cancer development.Journal of the Egyptian National Cancer Institute · 2023Review
- Association of Polymorphisms in miRNA Processing Genes With Type 2 Diabetes Mellitus and Its Vascular Complications in a Southern Chinese Population.Frontiers in endocrinology · 2019Article
- MicroRNA (miR)-433 and miR-22 dysregulations induce histone-deacetylase-6 overexpression and ciliary loss in cholangiocarcinoma.Hepatology (Baltimore, Md.) · 2018Article
- Association of variants of miRNA processing genes with cervical precancerous lesion risk in a southern Chinese population.Bioscience reports · 2018Article
- miRNA-Processing Gene Methylation and Cancer Risk.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2018Article
- Evaluating the Oncogenic and Tumor Suppressor Role of XPO5 in Different Tissue Tumor TypesAsian Pacific journal of cancer prevention : APJCP · 2018Article
- Origins of the enhanced affinity of RNA-protein interactions triggered by RNA phosphorodithioate backbone modification.Chemical communications (Cambridge, England) · 2017Article
- Solid-Phase Synthesis of RNA Analogs Containing Phosphorodithioate Linkages.Current protocols in nucleic acid chemistry · 2017Article
- Association of microRNA-related gene XPO5 rs11077 polymorphism with susceptibility to thyroid cancer.Medicine · 2017Article
- SGK1 affects RAN/RANBP1/RANGAP1 via SP1 to play a critical role in pre-miRNA nuclear export: a new route of epigenomic regulation.Scientific reports · 2017Article
- MicroRNA Processing and Human Cancer.Journal of clinical medicine · 2015Review
- Circulating biomarkers in renal cell carcinoma: the link between microRNAs and extracellular vesicles, where are we now?Journal of kidney cancer and VHL · 2014Article
- miRNA biogenesis: biological impact in the development of cancer.Cancer biology & therapy · 2014Review
- Article
- The significance of epigenetic alterations in lung carcinogenesis.Molecular biology reports · 2013Review
- Lin28b promotes head and neck cancer progression via modulation of the insulin-like growth factor survival pathway.Oncotarget · 2012Article
- Transcriptional targeting by microRNA-polycomb complexes: a novel route in cell fate determination.Cell cycle (Georgetown, Tex.) · 2012Article
- Stop the dicing in hematopoiesis: what have we learned?Cell cycle (Georgetown, Tex.) · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In line with their broad-based effects, microRNAs (miRNAs), small non-coding RNA molecules ~22 nucleotides long that silence target mRNAs, are thought to act as oncogenes or tumor suppressor genes based on their inhibition of tumor-suppressive and oncogenic mRNAs, respectively. We and others previously showed that global downregulation of miRNAs, a common feature of human tumors, is functionally relevant to oncogenesis as impairment of miRNA biogenesis enhanced transformation in both cancer cells and a K-Ras-driven model of lung cancer. The dysregulation of miRNA biosynthesis in cancer emerges as a cancer-specific mechanism that enhances its tumorigenic capacity. These observations are further supported by the fact that frameshift mutations of TARBP2 occur in sporadic and hereditary carcinomas with microsatellite instability and that DICER1 mutations are associated with familial pleuropulmonary blastoma. Accordingly, it was reported that reduced expression of miRNA-processing factors is associated with poor prognosis in lung cancer and ovarian cancer. Recently we have also demonstrated the presence of Exportin 5 (XPO5) inactivating mutations in tumors with microsatellite instability. This observed genetic defect is responsible for nuclear retention of pre-miRNAs, thereby reducing miRNA processing. The characterized mutant form of the XPO5 protein lacks a C-terminal region that contributes to the formation of the pre-miRNA/XPO5/Ran-GTP ternary complex and the protein itself, as well as pre-miRNAs accumulating in the nucleus of cancer cells. Most importantly, the restoration of XPO5 function reverses the impaired export of pre-miRNAs and has tumor suppressor features. Our data suggest a cancer-specific mechanism to guide the subcellular distribution of miRNA precursors and prevent them from being processed to the active mature miRNA. The control of the miRNA biosynthesis pathway is emerging as an important mechanism in defining the spatiotemporal pattern of miRNA expression in cancer cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.