ArticleBlood2011
Characterization of immune-matched hematopoietic transplantation in zebrafish.
Article in Blood, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 41 citations in OpenAlex.
- The sinusoidal hematopoietic niche is formed by Jam1a via Notch signaling in the zebrafish kidney.iScience · 2023Article
- Hematopoietic Stem and Progenitor Cell Identification and Transplantation in Zebrafish.Methods in molecular biology (Clifton, N.J.) · 2023Article
- A novel conditioning-free hematopoietic stem cell transplantation model in zebrafish.Blood advances · 2020Article
- Generation of foxn1/Casper Mutant Zebrafish for Allograft and Xenograft of Normal and Malignant Cells.Stem cell reports · 2020Article
- Uptake of osteoblast-derived extracellular vesicles promotes the differentiation of osteoclasts in the zebrafish scale.Communications biology · 2020Article
- Enrichment of hematopoietic stem/progenitor cells in the zebrafish kidney.Scientific reports · 2019Article
- Leveraging the zebrafish to model organ transplantation.Current opinion in organ transplantation · 2019Review
- Article
- Development of an In Vitro Assay to Quantitate Hematopoietic Stem and Progenitor Cells (HSPCs) in Developing Zebrafish Embryos.Journal of visualized experiments : JoVE · 2017Article
- Comprehensive validation of T- and B-cell deficiency in rag1-null zebrafish: Implication for the robust innate defense mechanisms of teleosts.Scientific reports · 2017Article
- A Functional Bioluminescent Zebrafish Screen for Enhancing Hematopoietic Cell Homing.Stem cell reports · 2017Article
- Understanding the regulation of vertebrate hematopoiesis and blood disorders - big lessons from a small fish.FEBS letters · 2016Review
- Zebrafish embryonic stromal trunk (ZEST) cells support hematopoietic stem and progenitor cell (HSPC) proliferation, survival, and differentiation.Experimental hematology · 2015Article
- Article
- Zebrafish as a Model for the Study of Human Myeloid Malignancies.BioMed research international · 2015Review
- Animal models of tuberculosis: zebrafish.Cold Spring Harbor perspectives in medicine · 2014Review
- The MHC class I genes of zebrafish.Developmental and comparative immunology · 2014Review
- Oceans of opportunity: exploring vertebrate hematopoiesis in zebrafish.Experimental hematology · 2014Review
- Repairing quite swimmingly: advances in regenerative medicine using zebrafish.Disease models & mechanisms · 2014Review
- Multiple divergent haplotypes express completely distinct sets of class I MHC genes in zebrafish.Immunogenetics · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
Evaluating hematopoietic stem cell (HSC) function in vivo requires a long-term transplantation assay. Although zebrafish are a powerful model for discovering the genetics of hematopoiesis, hematopoietic transplantation approaches have been underdeveloped. Here we established a long-term reconstitution assay in adult zebrafish. Primary and secondary recipients showed multilineage engraftment at 3 months after transplantation. Limiting dilution data suggest that at least 1 in 65 000 zebrafish marrow cells contain repopulating activity, consistent with mammalian HSC frequencies. We defined zebrafish haplotypes at the proposed major histocompatibility complex locus on chromosome 19 and tested functional significance through hematopoietic transplantation. Matching donors and recipients dramatically increased engraftment and percentage donor chimerism compared with unmatched fish. These data constitute the first functional test of zebrafish histocompatibility genes, enabling the development of matched hematopoietic transplantations. This lays the foundation for competitive transplantation experiments with mutant zebrafish HSCs and chemicals to test for effects on engraftment, thereby providing a model for human hematopoietic diseases and treatments not previously available.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.