ReviewAmerican journal of physiology. Regulatory, integrative and comparative physiology2011
The lighter side of BDNF.
Review in American journal of physiology. Regulatory, integrative and comparative physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04484558 (Anxiety and Depression Disorder in Patient Treated With rTPA for Mangment of Acute Ischemic Stroke), which is not on this map. Cited by 128 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Anxiety and Depression Disorder in Patient Treated With rTPA for Mangment of Acute Ischemic Stroke
Who cites it
128 citing papers in PubMed, 1 synthesis or guideline pooled it, 275 citations in OpenAlex.
- Association between Obesity and Circulating Brain-Derived Neurotrophic Factor (BDNF) Levels: Systematic Review of Literature and Meta-Analysis.International journal of molecular sciences · 2018Pooled it
- Trial
- Brain-derived neurotrophic factor in diabetes: A promising target for cognitive restoration.iScience · 2026Review
- Multisystemic Consequences of Brain-Derived Neurotrophic Factor (BDNF) Haploinsufficiency in the SD-BDNFtm1sage Rat Model.International journal of molecular sciences · 2026Review
- Targeting Sensory Neuropathies Through Neurotrophin-Based Approaches.Cellular and molecular neurobiology · 2026Review
- Qianzheng powder promotes facial nerve regeneration via BDNF/TrkB/CREB pathway activation.Regenerative therapy · 2026Article
- Non-invasive brain stimulation on functional capacity in prefrail older adults: a protocol for a randomised clinical trial.Frontiers in aging neuroscience · 2026Article
- Investigation of the Relationship Between Brain-Derived Neurotrophic Factor and Some Biochemical Parameters in Dairy Cows During the Transition Period.Veterinary medicine and science · 2025Article
- Assessing Exercise and Fitness-Related Brain Health Using Multi-modal Magnetic Resonance Imaging Outcomes.Advances in neurobiology · 2025Review
- Brain-Derived Neurotrophic Factor (BDNF) in Huntington's Disease: Neurobiology and Therapeutic Potential.Current neuropharmacology · 2025Review
- Oligodendrocyte Progenitor Cell Transplantation Reduces White Matter Injury in a Fetal Goat Model.CNS neuroscience & therapeutics · 2024Article
- Article
- Solubilized β-Glucan Supplementation in C57BL/6J Mice Dams Augments Neurodevelopment and Cognition in the Offspring Driven by Gut Microbiome Remodeling.Foods (Basel, Switzerland) · 2024Article
- Article
- The BDNF Val66Met polymorphism and health-related quality of life in youth with obesity.Physiological reports · 2024Article
- Exercise and Protection from Age-Related Cognitive Decline.Current topics in behavioral neurosciences · 2024Review
- GQIcombi application to subdue glioma via differentiation therapy.Frontiers in oncology · 2024Article
- Targeting BDNF with acupuncture: A novel integrated strategy for diabetes and depression comorbidity.Heliyon · 2023Review
- Understanding the Gut-Brain Axis and Its Therapeutic Implications for Neurodegenerative Disorders.Nutrients · 2023Review
- Signal processing in the vagus nerve: Hypotheses based on new genetic and anatomical evidence.Biological psychology · 2023Review
68 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Brain-derived neurotrophic factor (BDNF) mediates energy metabolism and feeding behavior. As a neurotrophin, BDNF promotes neuronal differentiation, survival during early development, adult neurogenesis, and neural plasticity; thus, there is the potential that BDNF could modify circuits important to eating behavior and energy expenditure. The possibility that "faulty" circuits could be remodeled by BDNF is an exciting concept for new therapies for obesity and eating disorders. In the hypothalamus, BDNF and its receptor, tropomyosin-related kinase B (TrkB), are extensively expressed in areas associated with feeding and metabolism. Hypothalamic BDNF and TrkB appear to inhibit food intake and increase energy expenditure, leading to negative energy balance. In the hippocampus, the involvement of BDNF in neural plasticity and neurogenesis is important to learning and memory, but less is known about how BDNF participates in energy homeostasis. We review current research about BDNF in specific brain locations related to energy balance, environmental, and behavioral influences on BDNF expression and the possibility that BDNF may influence energy homeostasis via its role in neurogenesis and neural plasticity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.