ArticleScience translational medicine2011
Pump-probe imaging differentiates melanoma from melanocytic nevi.
Article in Science translational medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
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Who cites it
61 citing papers in PubMed, 152 citations in OpenAlex.
- Increased dendritic cell density and altered melanin patterns distinguish melanoma from Nevi on CRFF-OCT: A pilot study toward noninvasive diagnosis.Journal of the American Academy of Dermatology · 2026Article
- Article
- Angle-resolved Measurements Reveal the Origin of Signal Anisotropy in Pump-probe Microscopy.bioRxiv : the preprint server for biology · 2025Article
- On the importance of simultaneous label-free multimodal nonlinear optical imaging for biomedical applications.APL photonics · 2025Article
- Noninvasive identification of carbon-based black pigments with pump-probe microscopy.Science advances · 2024Article
- Numerical study of transient absorption saturation in single-layer graphene for optical nanoscopy applications.Scientific reports · 2024Article
- Roadmap on Label-Free Super-Resolution Imaging.Laser & photonics reviews · 2023Article
- Nondestructive Nonlinear Optical Microscopy Revealed the Blackening Mechanism of Ancient Chinese Jades.Research (Washington, D.C.) · 2023Article
- Optical characteristics of the skin with dark circles using pump-probe imaging.Scientific reports · 2022Article
- Contrast mechanisms in pump-probe microscopy of melanin.Optics express · 2022Article
- Melanin concentration maps by label-free super-resolution photo-thermal imaging on melanoma biopsies.Biomedical optics express · 2022Article
- Label-Free Delineation of Human Uveal Melanoma Infiltration With Pump-Probe Microscopy.Frontiers in oncology · 2022Article
- Harnessing non-destructive 3D pathology.Nature biomedical engineering · 2021Review
- Melanins as Sustainable Resources for Advanced Biotechnological Applications.Global challenges (Hoboken, NJ) · 2021Review
- Multimodal Metabolic Imaging Reveals Pigment Reduction and Lipid Accumulation in Metastatic Melanoma.BME frontiers · 2021Article
- Quantitative Autofluorescence Imaging of A375 Human Melanoma Cell Samples: A Pilot Study.Journal of lasers in medical sciences · 2021Article
- Inkjet Printing of Synthesized Melanin Nanoparticles as a Biocompatible Matrix for Pharmacologic Agents.Nanomaterials (Basel, Switzerland) · 2020Article
- Transient absorption microscopy: Technological innovations and applications in materials science and life science.The Journal of chemical physics · 2020Article
- Quantitative imaging of intraerythrocytic hemozoin by transient absorption microscopy.Journal of biomedical optics · 2019Article
- Analysis of Melanin Structure and Biochemical Composition in Conjunctival Melanocytic Lesions Using Pump-Probe Microscopy.Translational vision science & technology · 2019Article
1 more citing papers are in PubMed but not listed here.
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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Melanoma diagnosis is clinically challenging: the accuracy of visual inspection by dermatologists is highly variable and heavily weighted toward false positives. Even the current gold standard of biopsy results in varying diagnoses among pathologists. We have developed a multiphoton technique (based on pump-probe spectroscopy) that directly determines the microscopic distribution of eumelanin and pheomelanin in pigmented lesions of human skin. Our initial results showed a marked difference in the chemical variety of melanin between nonmalignant nevi and melanoma, as well as a number of substantial architectural differences. We examined slices from 42 pigmented lesions and found that melanomas had an increased eumelanin content compared to nonmalignant nevi. When used as a diagnostic criterion, the ratio of eumelanin to pheomelanin captured all investigated melanomas but excluded three-quarters of dysplastic nevi and all benign dermal nevi. Additional evaluation of architectural and cytological features revealed by multiphoton imaging, including the maturation of melanocytes, presence of pigmented melanocytes in the dermis, number and location of melanocytic nests, and confluency of pigmented cells in the epidermis, further increased specificity, allowing rejection of more than half of the remaining false-positive results. We then adapted this multiphoton imaging technique to hematoxylin and eosin (H&E)-stained slides. By adding melanin chemical contrast to H&E-stained slides, pathologists will gain complementary information to increase the ease and accuracy of melanoma diagnosis.
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