Evidence map›Paper›PMID 21346029›Full record

ArticleThe Journal of general virology2011

Molecular characterization of a new species in the genus Alphacoronavirus associated with mink epizootic catarrhal gastroenteritis.

Anastasia N Vlasova, Rebecca Halpin, Shiliang Wang, Elodie Ghedin, David J Spiro, Linda J Saif

Abstract read
In one paragraph

Article in The Journal of general virology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 65 citations in OpenAlex.

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  16. Genome Sequence of aMicrobiology resource announcements · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Anastasia N VlasovaFood Animal Health Research Program, Ohio Agricultural Research and Development Center, Ohio State University, 1680 Madison Avenue, Wooster, OH 44691, USA.
Rebecca HalpinViral Genomics Group, The J. Craig Venter Institute, 9704 Medical Center Drive, Rockville, MD 20850, USA.
Shiliang WangViral Genomics Group, The J. Craig Venter Institute, 9704 Medical Center Drive, Rockville, MD 20850, USA.
Elodie GhedinDepartment of Computational and Systems Biology, Center for Vaccine Research, University of Pittsburgh School of Medicine, 3501 Fifth Avenue, Pittsburgh, PA 15261, USA.
David J SpiroViral Genomics Group, The J. Craig Venter Institute, 9704 Medical Center Drive, Rockville, MD 20850, USA.
Linda J SaifFood Animal Health Research Program, Ohio Agricultural Research and Development Center, Ohio State University, 1680 Madison Avenue, Wooster, OH 44691, USA.
J. Craig Venter Institute · USUniversity of Pittsburgh · US

Funding

Antigenic Relationships of SARS and Animal CoronavirusesR21AI062763 · NIAID · OHIO STATE UNIVERSITY · PI SAIF, LINDA J. · 2005 to 2006
$406k
NIAID NIH HHS HHSN272200900007CNIAID NIH HHS N01 AI030071NIAID NIH HHS R21 AI062763
6 · The paper itself

Abstract

A coronavirus (CoV) previously shown to be associated with catarrhal gastroenteritis in mink (Mustela vison) was identified by electron microscopy in mink faeces from two fur farms in Wisconsin and Minnesota in 1998. A pan-coronavirus and a genus-specific RT-PCR assay were used initially to demonstrate that the newly discovered mink CoVs (MCoVs) were members of the genus Alphacoronavirus. Subsequently, using a random RT-PCR approach, full-genomic sequences were generated that further confirmed that, phylogenetically, the MCoVs belonged to the genus Alphacoronavirus, with closest relatedness to the recently identified but only partially sequenced (fragments of the polymerase, and full-length spike, 3c, envelope, nucleoprotein, membrane, 3x and 7b genes) ferret enteric coronavirus (FRECV) and ferret systemic coronavirus (FRSCV). The molecular data presented in this study provide the first genetic evidence for a new coronavirus associated with epizootic catarrhal gastroenteritis outbreaks in mink and demonstrate that MCoVs possess high genomic variability and relatively low overall nucleotide sequence identities (91.7 %) between contemporary strains. Additionally, the new MCoVs appeared to be phylogenetically distant from human (229E and NL63) and other alphacoronaviruses and did not belong to the species Alphacoronavirus 1. It is proposed that, together with the partially sequenced FRECV and FRSCV, they comprise a new species within the genus Alphacoronavirus.

Indexed as

MinkAnimalsBase SequenceCoronavirusFecesGastroenteritisGenome, ViralMolecular Sequence DataPhylogenyViral ProteinsViral Proteins

Identifiers

PMID21346029
PMCPMC3168282
OpenAlexW2124510607

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.