ArticleInvestigative ophthalmology & visual science2011
Interferon-gamma, macrophages, and virus spread after HSV-1 injection.
Article in Investigative ophthalmology & visual science, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
12 citing papers in PubMed, 17 citations in OpenAlex.
- Review
- STING activates ZBP1-mediated PANoptosis to defend against HSV-1 retinal infection.Journal of neuroinflammation · 2025Article
- Mice with type I interferon signaling deficiency are prone to epilepsy upon HSV-1 infection.Virologica Sinica · 2024Article
- Infectious Eye Diseases and Prevention Control.Microorganisms · 2023Article
- Type I Interferon Signaling Is Critical During the Innate Immune Response to HSV-1 Retinal Infection.Investigative ophthalmology & visual science · 2022Article
- Pathogenesis and virulence of herpes simplex virus.Virulence · 2021Review
- Pathobiology and treatment of viral keratitis.Experimental eye research · 2021Review
- Intramuscular Vaccination With the HSV-1(VC2) Live-Attenuated Vaccine Strain Confers Protection Against Viral Ocular Immunopathogenesis Associated With γδT Cell Intracorneal Infiltration.Frontiers in immunology · 2021Article
- Case Report: Rapid Recognition and Immune Modulation of Secondary HLH Due to Disseminated HSV Infection.Frontiers in pediatrics · 2021Article
- Pathological processes activated by herpes simplex virus-1 (HSV-1) infection in the cornea.Cellular and molecular life sciences : CMLS · 2019Review
- Complexity of Interferon-γ Interactions with HSV-1.Frontiers in immunology · 2014Review
- Immunological aspects of acute and recurrent herpes simplex keratitis.Journal of immunology research · 2014Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
purposeAfter uniocular anterior chamber (AC) injection of HSV-1, the anterior segment of BALB/c mice becomes inflamed and infected; however, virus does not spread from the anterior segment to cause retinitis in the injected eye. The purpose of these studies was to determine whether interferon (IFN-)-γ and Mac-1(+) cells play a role in preventing direct anterior-to-posterior spread of HSV-1 in the injected eye.
methodsOne AC of adult female BALB/c mice was injected with HSV-1 (KOS). The location of IFN-α, IFN-β, and IFN-γ in the injected eye was determined by immunofluorescence, and mRNA expression was quantified by qPCR. Injected eyes of IFN-γ knockout or clodronate-treated macrophage-depleted mice were examined to determine whether the absence of IFN-γ or Mac-1(+) macrophages affected the sites or timing of virus spread.
resultsIFN-α, IFN-β, and IFN-γ were observed in the anterior segment of injected eyes through 72 hours and mRNA levels of IFN-β and IFN-γ were increased in virus-infected eyes 48 to 120 hours after infection. However, the absence of IFN-γ or macrophages did not affect either the sites or the timing of HSV-1 infection in injected eyes.
conclusionsProtection of the retina of the injected eye does not depend on a single cell type or cytokine. In addition, in the eye, as in other sites of the body, there are redundancies in the innate response to virus infection.
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