ReviewAmerican journal of physiology. Renal physiology2011
Luminal flow regulates NO and O2(-) along the nephron.
Review in American journal of physiology. Renal physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 34 citations in OpenAlex.
- Luminal flow in the connecting tubule induces afferent arteriole vasodilation.Clinical and experimental nephrology · 2025Article
- Luminal Flow in the Connecting Tubule induces Afferent Arteriole Vasodilation.bioRxiv : the preprint server for biology · 2024Article
- Osteoclastogenesis Requires Primary Cilia Disassembly and Can Be Inhibited by Promoting Primary Cilia Formation Pharmacologically.Cells, tissues, organs · 2024Article
- Ex Vivo Analysis of Mechanically Activated Ca2+ Transients in Urothelial Cells.Journal of visualized experiments : JoVE · 2022Article
- Tissue Chips and Microphysiological Systems for Disease Modeling and Drug Testing.Micromachines · 2021Review
- Nephron-Specific Disruption of Polycystin-1 Induces Cyclooxygenase-2-Mediated Blood Pressure Reduction Independent of Cystogenesis.Journal of the American Society of Nephrology : JASN · 2020Article
- Pulsatile flow through idealized renal tubules: Fluid-structure interaction and dynamic pathologies.Mathematical biosciences and engineering : MBE · 2019Article
- Genetic polymorphisms associated with reactive oxygen species and blood pressure regulation.The pharmacogenomics journal · 2019Review
- Tubule-vascular feedback in renal autoregulation.American journal of physiology. Renal physiology · 2019Review
- Free radical scavenging reverses fructose-induced salt-sensitive hypertension.Integrated blood pressure control · 2018Article
- Sexual Dimorphic Pattern of Renal Transporters and Electrolyte Homeostasis.Journal of the American Society of Nephrology : JASN · 2017Article
- Article
- A computational model for simulating solute transport and oxygen consumption along the nephrons.American journal of physiology. Renal physiology · 2016Article
- Paracellular epithelial sodium transport maximizes energy efficiency in the kidney.The Journal of clinical investigation · 2016Article
- Role of Phosphodiesterase 5 and Cyclic GMP in Hypertension.Current hypertension reports · 2016Review
- An emerging role for gasotransmitters in the control of breathing and ionic regulation in fish.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2016Review
- Asymmetric Dimethylarginine and Its Relation As a Biomarker in Nephrologic Diseases.Biomarker insights · 2016Review
- TRPV4 mediates flow-induced increases in intracellular Ca in medullary thick ascending limbs.Acta physiologica (Oxford, England) · 2015Article
- Reactive oxygen species as important determinants of medullary flow, sodium excretion, and hypertension.American journal of physiology. Renal physiology · 2015Review
- Angiotensin II-induced hypertension blunts thick ascending limb NO production by reducing NO synthase 3 expression and enhancing threonine 495 phosphorylation.American journal of physiology. Renal physiology · 2015Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Urinary flow is not constant but in fact highly variable, altering the mechanical forces (shear stress, stretch, and pressure) exerted on the epithelial cells of the nephron as well as solute delivery. Nitric oxide (NO) and superoxide (O(2)(-)) play important roles in various processes within the kidney. Reductions in NO and increases in O(2)(-) lead to abnormal NaCl and water absorption and hypertension. In the last few years, luminal flow has been shown to be a regulator of NO and O(2)(-) production along the nephron. Increases in luminal flow enhance fluid, Na, and bicarbonate transport in the proximal tubule. However, we know of no reports directly addressing flow regulation of NO and O(2)(-) in this segment. In the thick ascending limb, flow-stimulated NO and O(2)(-) formation has been extensively studied. Luminal flow stimulates NO production by nitric oxide synthase type 3 and its translocation to the apical membrane in medullary thick ascending limbs. These effects are mediated by flow-induced shear stress. In contrast, flow-induced stretch and NaCl delivery stimulate O(2)(-) production by NADPH oxidase in this segment. The interaction between flow-induced NO and O(2)(-) is complex and involves more than one simply scavenging the other. Flow-induced NO prevents flow from increasing O(2)(-) production via cGMP-dependent protein kinase in thick ascending limbs. In macula densa cells, shear stress increases NO production and this requires that the primary cilia be intact. The role of luminal flow in NO and O(2)(-) production in the distal tubule is not known. In cultured inner medullary collecting duct cells, shear stress enhances nitrite accumulation, a measure of NO production. Although much progress has been made on this subject in the last few years, there are still many unanswered questions.
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